1616667-76-5Relevant academic research and scientific papers
Microwave-assisted synthesis of C-8 aryl and heteroaryl inosines and determination of their inhibitory activities against Plasmodium falciparum purine nucleoside phosphorylase
Gigante, Alba,Priego, Eva-María,Sánchez-Carrasco, Paula,Ruiz-Pérez, Luis Miguel,Vande Voorde, Johan,Camarasa, María- José,Balzarini, Jan,González-Pacanowska, Dolores,Pérez-Pérez, María-Jesús
, p. 459 - 465 (2014)
8-Arylinosines have been scarcely studied for therapeutic purposes, probably due to difficulties in their synthesis. The recently described direct arylation reaction at position 8 of purine nucleosides has been employed to synthesize a series of 8-aryl and 8-pyridylinosines. These compounds have been studied for hydrolytic stability and subjected to biological evaluation. Three compounds have shown a pronounced specific inhibition of Plasmodium falciparum-encoded purine nucleoside phosphorylase, an important target for antimalarial chemotherapy.
