161670-35-5

Basic information

• Product Name: L-Leucine, N-[(1,1-dimethylethoxy)carbonyl]-O-methyl-L-tyrosyl-N-methyl-, methyl ester
• CAS NO: 161670-35-5
• Molecular Formula: C23H36N2O6
• Molecular Weight: 436.549
• Mol File: 161670-35-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: L-Leucine, N-[(1,1-dimethylethoxy)carbonyl]-O-methyl-L-tyrosyl-N-methyl-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Leucine, N-[(1,1-dimethylethoxy)carbonyl]-O-methyl-L-tyrosyl-N-methyl-, methyl ester(161670-35-5)
• EPA Substance Registry System: L-Leucine, N-[(1,1-dimethylethoxy)carbonyl]-O-methyl-L-tyrosyl-N-methyl-, methyl ester(161670-35-5)

Safety Data

• Hazardous Substances Data: 161670-35-5(Hazardous Substances Data)

Upstream product

• 130994-88-6 methyl N-methyl-N-(tert-butoxycarbonyl)-L-leucinate 
• 53363-89-6 N-t-butoxycarbonyl-N-methyl-L-leucine 
• 35026-08-5 N-methyl-L-leucine methyl ester 
• 53267-93-9 O-methyl-N-tert-butoxycarbonyl-L-tyrosine 

Downstream Products

• 161670-36-6 Boc-Phe(4-OMe)-MeLeu-OH 
• 161670-37-7 [(S)-1-{[(S)-1-((S)-1-{(S)-1-Hydroxy-2-[5-(3-methyl-butylcarbamoyl)-pentylcarbamoyl]-ethyl}-3-methyl-butylcarbamoyl)-3-methyl-butyl]-methyl-carbamoyl}-2-(4-methoxy-phenyl)-ethyl]-carbamic acid tert-butyl ester 
• 189162-94-5 (3S,4S)-4-((S)-2-{[(S)-2-Amino-3-(4-methoxy-phenyl)-propionyl]-methyl-amino}-4-methyl-pentanoylamino)-3-hydroxy-6-methyl-heptanoic acid [5-(3-methyl-butylcarbamoyl)-pentyl]-amide 

Relevant articles and documents

New renin inhibitors containing pseudodipeptidic units in P 3-P2 and P1-P1′ positions

A series of four non-peptidic renin inhibitors have been designed and synthesized. All of them contain in their molecule (3S,4S)-4-amino-5-cyclohexyl- 3-hydroxypentanoic acid (ACHPA), a hydrophobic portion at the C-terminus and a second dipeptide-like tra

New renin inhibitors containing aliphatic or aromatic amides at the C-terminus

Five renin inhibitors, Iva-Pro-Phe(4-OMe)-MeLeu-Sta-εAhx-IAA (18), Iva-εAhx-Phe(4-OMe)-MeLeu-Sta-εAhx-IAA (23), H-εAhx-Phe(4-OMe)-His-Sta-εAhx-FBZA (36), H-εAhx-Phe(4-OMe)-His-Sta-εAhx-MBZA (45), and H-Phe (4-OMe)-His-Sta-εAhx-FBZA (48) have been synthesized in search of structures of improved biological properties. All synthesized inhibitors were resistant to chymotrypsin activity. Inhibitors 18 and 23 were insoluble in buffers, pH 7.4 and 2.0, 36, 45 and 48 were very good soluble in buffer pH 2.0 and poorly in buffer pH 7.4. Experimentally determined 1-octanol/pH 7.4 buffer partition coefficients (log P) of 36, 45 and 48 were above 1. Log P values of 18, 23, 36, 45 and 48 were 6.57, 6.91, 2.48, 2.09 and 2.00 respectively. The inhibitory potency in vitro of 18, 23, 36, 45 and 48 expressed as IC50 was 7.5 · 10-5, 5.0 · 10-6, 7.5 · 10-3, 1.0 · 10-4 and 2.5 · 10-5 M/l respectively.