1616735-31-9Relevant academic research and scientific papers
Novel 3-arylethynyl-substituted thieno[3,4-b]pyrazine derivatives as human transglutaminase 2 inhibitors
Kim, Nayeon,Kwak, Se Hun,Lee, Seon-Hyeong,Juvekar, Vinayak,Lee, Byung-Il,Ahn, Hee-Chul,Kim, Soo-Youl,Gong, Young-Dae
, p. 4932 - 4940 (2014/07/07)
In the process of optimization, we developed a novel core skeleton of thieno[3,4-b]pyrazine viaGK-13. The derivatives synthesized were shown to inhibit TGase 2 activity in cancer cells. Some of the hit compounds such as the arylethynyl group-coupled thieno[3,4-b]pyrazine derivatives were shown to exhibit promising activity for use as potential therapeutic small-molecules in renal cancer by inhibiting TGase 2 activity. This journal is the Partner Organisations 2014.
