1616738-60-3Relevant academic research and scientific papers
Access to novel imidazo[1,5-a]pyrazine scaffolds by the combined use of a three-component reaction and a base-assisted intramolecular cyclization
Attanasi, Orazio A.,Favi, Gianfranco,Giorgi, Gianluca,Majer, Roberta,Perrulli, Francesca Romana,Santeusanio, Stefania
, p. 4610 - 4619 (2014/06/24)
A novel and practical two-step approach to an intriguing class of imidazo[1,5-a]pyrazines with exocyclic CX (X = CH2, O) bonds is described. The process utilizes a sequential three-component reaction of propargyl amine or aminoester, 1,2-diaza-1,3-dienes and isothiocyanates to furnish functionalized 2-thiohydantoins which are transformed into thiohydantoin-fused tetrahydropyrazines by subsequent regioselective base-promoted cyclization. This journal is
