1616784-13-4Relevant academic research and scientific papers
Amides are excellent mimics of phosphate internucleoside linkages and are well tolerated in short interfering RNAs
Mutisya, Daniel,Selvam, Chelliah,Lunstad, Benjamin D.,Pallan, Pradeep S.,Haas, Amanda,Leake, Devin,Egli, Martin,Rozners, Eriks
, p. 6542 - 6551 (2014/07/08)
RNA interference (RNAi) has become an important tool in functional genomics and has an intriguing therapeutic potential. However, the current design of short interfering RNAs (siRNAs) is not optimal for in vivo applications. Non-ionic phosphate backbone m
