1616784-91-8Relevant academic research and scientific papers
Enantioselective Prins cyclization: BINOL-derived phosphoric acid and CuCl synergistic catalysis
Lalli, Claudia,Van De Weghe, Pierre
supporting information, p. 7495 - 7498 (2014/07/07)
The first catalytic enantioselective Prins cyclization is disclosed. The reaction is catalyzed by the combination of a chiral BINOL-derived bis-phosphoric acid and CuCl. The process consists of a tandem Prins/Friedel-Crafts cyclization that affords the hexahydro-1H-benzo[f] isochromenes products with three new contiguous stereogenic centers in high yields, and good enantio- and excellent diastereoselectivities. the Partner Organisations 2014.
