1616869-69-2Relevant academic research and scientific papers
The ninhydrin core as carbonyl source to access 2-(2′-hydroxyaryl)benzimidazoles exploiting the ortho selectivity of ninhydrin-phenol adducts
Das, Suven,Maity, Suvendu,Ghosh, Prasanta,Dutta, Arpita
, p. 2862 - 2872 (2021/08/13)
Although ninhydrin is an essential analytical tool in biochemical and forensic sciences, for the past several years, it has been employed as efficient building block for diverse organic scaffolds. In the present work, the ortho selectivity of ninhydrin-phenol adducts has been exploited to obtain 2-(2′-hydroxyaryl)benzimidazoles which are well known excited state intramolecular proton transfer (ESIPT) fluorophores. Under acidic condition, 3-(2-hydroxyaroyl)isoindolin-1-one intermediate generated in situ from ninhydrin-phenol adducts was treated with o-phenylenediamine resulting benzimidazole scaffolds via a two-step one pot strategy.
Facile synthesis of 3H,3′H-spiro[benzofuran-2,1′-isoindole]-3, 3′-diones using monobromomalononitrile (MBM) as an efficient organo-brominating agent
Kundu, Ashis,Pathak, Sudipta,Debnath, Kamalesh,Pramanik, Animesh
, p. 3960 - 3968 (2014/07/08)
An efficient methodology for the synthesis of 3H,3′H- spiro[benzofuran-2,1′-isoindole]-3,3′-diones has been developed where monobromomalononitrile (MBM) has been employed as a non-hazardous brominating agent under ambient reaction condition. The intrinsic advantages of the methodology are the utilization of simple and easily available starting materials and non-toxic reagents, operational simplicity, and good yields of the products with high atom-economy.
