161691-26-5Relevant articles and documents
An efficient route to the pyrrolizidine ring system via an N-acyl anion cyclisation process
Murray, Anthony,Proctor, George R.,Murray, P. John
, p. 3757 - 3766 (2007/10/03)
An enantioselective route to the pyrrolizidine ring system has been developed which uses an N-acyl anion cyclisation reaction as the key step. This methodology has provided the natural pyrrolizidines (-)-(1R, 8S)-1-hydroxy-pyrrolizidine 7, (-)-pyrrolizidin-1-ene-3-one 9 and (±)-trachelanthamidine 14. Extension of the process to an N-propionyl substrate provides ready access to a series of 2-methyl pyrrolizidines.
