1616981-10-2Relevant academic research and scientific papers
Improved synthesis of pyridyl-biaryl ring systems via benzidine rearrangements
Leung, Gulice Y.C.,William, Anthony D.,Johannes, Charles W.
supporting information, p. 3950 - 3953 (2014/07/08)
The acid-catalyzed benzidine rearrangement of diazo compounds is known to involve several rearrangements with the major pathway being a [5,5] sigmatropic rearrangement to provide 4,4′-diaminobiaryls. A limitation of this rearrangement has been poor conversions with pyridyl systems. Herein, we address this long standing issue to furnish hetero-biaryls via a pyridinium salt in the presence of trimethylsilyl iodide.
