16170-10-8

Basic information

• Product Name: DL-threo-1,3-Dihydroxy-2-myristoylamino-trans-octadecen-⁽⁴⁾
• CAS NO: 16170-10-8
• Molecular Weight: 509.857
• Mol File: 16170-10-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: DL-threo-1,3-Dihydroxy-2-myristoylamino-trans-octadecen-⁽⁴⁾(CAS DataBase Reference)
• NIST Chemistry Reference: DL-threo-1,3-Dihydroxy-2-myristoylamino-trans-octadecen-⁽⁴⁾(16170-10-8)
• EPA Substance Registry System: DL-threo-1,3-Dihydroxy-2-myristoylamino-trans-octadecen-⁽⁴⁾(16170-10-8)

Safety Data

• Hazardous Substances Data: 16170-10-8(Hazardous Substances Data)

Upstream product

• 96040-13-0 2-nitro-4-octadecine-1,3-diol 
• 2733-33-7 (+/-)-threo-2-amino-octadec-4-yne-1,3-diol 
• 2673-72-5 (2S,3R,E)-2-aminooctadec-4-ene-1,3-diol hydrochloride 
• 123-78-4 (2S,3R,4E)-2-amino-4-octadecene-1,3-diol 
• 112-64-1 tetradecanoyl chloride 
• 123-78-4 dl-threo-sphingosine 

Downstream Products

• 17673-67-5 DL-threo-1-(Triphenylmethoxy)-2-myristoylamino-3-hydroxy-trans-octadecen-⁽⁴⁾ 

Relevant articles and documents

Chiral combinatorial preparation and biological evaluation of unique ceramides for inhibition of sphingomyelin synthase

Enantiomers or diastereomers of chiral bioactive compounds often exhibit different biological and toxicological properties. Here, we report the efficient synthesis of four stereoisomers of sphingosine and derivatization of unique chiral ceramides through a combinatorial chemistry by solid-phase activated resin ester. In addition, to test the effectivity of stereochemistry of ceramide, we demonstrated a cell-based assay of sphingomyelin synthase inhibition in the presence ofchiral unique ceramides, which suggested that libraries of this sort will be a rich source of biologically active synthetic molecules.

Inhibitory activity of a ceramide library on interleukin-4 production from activated T cells

Allergic diseases are hypersensitivity disorders associated with the production of specific immunoglobulin E (IgE) to environmental allergens. Interleukin (IL)-4, produced primarily by CD4+ T cells, is an important stimulus for the switch of th