161715-20-4Relevant articles and documents
Syntheses and pharmacokinetic studies of prodrug esters for the development of oral carbapenem, L-084
Isoda, Takeshi,Ushirogochi, Hideki,Satoh, Koichi,Takasaki, Tsuyoshi,Yamamura, Itsuki,Sato, Chisato,Mihira, Ado,Abe, Takao,Tamai, Satoshi,Yamamoto, Shigeki,Kumagai, Toshio,Nagao, Yoshimitsu
, p. 241 - 247 (2006)
We discovered an orally active carbapenem, L-084, through pharmacokinetic studies on various prodrug esters of (1R,5S,6S)-6-[(R)-1-hydroxyethyl]-1-methyl- 2-[1-(1,3-thiazolin-2-yl)azetidin-3-yl]thio-1-carbapen-2-em-3-carboxylic acid (LJC11,036). L-084 showed a strong antimicrobial activity against Gram-positive and Gram-negative bacteria and exhibited the highest intestinal absorption among synthesized prodrugs of LJC11,036. Japan Antibiotics Research Association.
Preparation method of high-purity tebipenem pivoxil crystals
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Paragraph 0021, (2019/01/17)
The invention discloses a preparation method of high-purity tebipenem pivoxil crystals. The method comprises the following steps: adding a first solvent to crude tebipenem pivoxil, and performing stirring to obtain a primary dissolved product; adding a second solvent dropwise to the primary dissolved product at a reaction temperature, and then performing stirring for crystallization, wherein the first solvent contains water; the second solvent is acetonitrile; the reaction temperature is 0-60 DEG C. The tebipenem pivoxil crystals with high purity and low solvent residue content can be preparedwith the method.