161716-23-0

Basic information

• Product Name: 2-(4-chlorophenyl)phthalazin-1(2H)-one
• CAS NO: 161716-23-0
• Molecular Weight: 256.691
• Mol File: 161716-23-0.mol

Chemical Properties

• CAS DataBase Reference: 2-(4-chlorophenyl)phthalazin-1(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-chlorophenyl)phthalazin-1(2H)-one(161716-23-0)
• EPA Substance Registry System: 2-(4-chlorophenyl)phthalazin-1(2H)-one(161716-23-0)

Safety Data

• Hazardous Substances Data: 161716-23-0(Hazardous Substances Data)

Usage

Type of compound

Phthalazinone derivative

Contains

A phenyl group with a chloro-substituent

Potential applications

Pharmaceutical research

Possible biological activity

Beneficial for medical purposes

Role in drug development

Candidate for further investigation

Potential use

Therapeutic agent for various conditions

Additional research needed

To fully understand its potential uses and properties

Upstream product

• 90-02-8 salicylaldehyde 

Relevant articles and documents

Access to phthalazinones via palladium-catalyzed three-component cycloamino-carbonylation of 2-formylaryl tosylates, hydrazines and CO

The palladium-catalyzed three-component cycloaminocarbonylation of 2-formylaryl tosylates with hydrazines and carbon monoxide has been established, which provides an efficient method for synthesis of substituted phthalazinones. In addition, by applying this protocol as the key step, Hydralazine can easily be synthesized in 65% yield.

Phtalazin derivatives and their use as pesticides

The invention provides compounds of formula: wherein the symbols are as defined in the description, which possess utility as pesticides (e.g. herbicides and insecticides).

A trans-Folded Alkene System: Synthesis, Structure and Isomerization of 2,2'-Diaryl-1,1'-bi(1,2-dihydrophthalazinylidenes)

A series of 2,2'-diaryl-1,1'-bi(1,2-dihydrophthalazinylidenes) have been synthesized from 1-hydroxy-2-aryl-1,2-dihydrophthalazines.An X-ray crystal structure showed relief of strain in these new ylidenes by a trans-folding of the alkene linkage.The mechanism of their formation was probed with additives such as sulphur, N-phenylmaleimide, and dimethyl acetylenedicarboxylate which interacted with intermediates in the reaction and gave further interesting new ylidene structures.The mechanism of trans-cis isomerization of the biphthalazinylidenes was studied using 270 MHz 1 H-NMR spectroscopy to measure the kinetics and activation parameters for the isomerization.X-Ray crystal structures of the following compounds are reported: 2,2'(p-bromophenyl)-trans-1,1'-bi--4--1-phenyl-3,4-dihydropyrrole-2,5-dione, (10d); dimethyl 3-(2-phenyl-1,2-dihydrophthalazin-1-ylidene)-2-oxobutanedioate (11), and dimethyl 2-acetoxy-3-(2-phenyl-1,2-dihydrophthalazin-1-yl)but-2-ene-1,4-dioate (12).