16174-74-6

Upstream product

• 88-67-5 2-Iodobenzoic acid 
• 106-45-6 para-thiocresol 
• 40400-15-5 2-(2-iodophenyl)acetonitrile 
• 16174-72-4 2-(4-methylthiophenoxy)benzyl alcohol 
• 16174-73-5 2-(p-tolylsulfanyl)benzyl chloride 
• 143-33-9 sodium cyanide 

Downstream Products

• 16174-75-7 2-[2-(p-tolylsulfanyl)phenyl]acetic acid 
• 1392204-39-5 (+/-)-2-[2-(p-tolylsulfenyl)phenyl]hex-4-enenitrile 
• 1392204-34-0 (+/-)-2-(prop-2-ynyl)-2-[2-(p-tolylsulfenyl)phenyl]pent-4-enenitrile 
• 1392204-35-1 (+/-)-2-(prop-2-ynyl)-2-[2-(p-tolylsulfenyl)phenyl]hex-4-enenitrile 
• 1392204-38-4 (+/-)-2-[2-(p-tolylsulfenyl)phenyl]pent-4-enenitrile 
• 1392204-41-9 (+/-)-(Z)-4-methyl-5-phenyl-2-(2-(p-tolylsulfenyl)phenyl)pent-4-enenitrile 
• 1392204-40-8 (+/-)-(E)-4-methyl-5-phenyl-2-(2-(p-tolylsulfenyl)phenyl)pent-4-enenitrile 

Relevant academic research and scientific papers

Asymmetric intramolecular Pauson-Khand reaction mediated by a remote sulfenyl or sulfinyl group

In this work, we report the use of the asymmetric intramolecular Pauson-Khand reactions of 4-aryl-4-cyano-1,6-enynes for obtaining enantiomerically enriched bicyclo[3.3.0]octenones, and the influence of both the quaternary stereocenter and the sulfur functions located at ortho-position of the aryl group, on their stereoselectivity and reactivity. The sulfenyl derivatives bearing substituted or unsubstituted triple bonds and mono- and disubstituted alkene moieties afford bicyclo[3.3.0]octenones in high yields with complete diastereocontrol. These results are explained by assuming the association of the lone electron pair at sulfur to the Co-alkyne complexes.