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161745-33-1

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161745-33-1 Usage

General Description

(R)-2,6-dimethyl-1,2,3,4-tetrahydroquinoline is a chemical compound with the molecular formula C11H15N. It is a bicyclic compound with a tetrahydroquinoline ring structure and two methyl groups attached to the second and sixth carbon atoms. This chemical is commonly used as a building block in the synthesis of pharmaceuticals, agrochemicals, and other fine chemicals. It has an important role as an intermediate in organic synthesis and can be used in the production of a variety of different compounds. Additionally, it has been studied for its potential biological and pharmacological activities, including its potential as an antiviral and anticonvulsant agent.

Check Digit Verification of cas no

The CAS Registry Mumber 161745-33-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,1,7,4 and 5 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 161745-33:
(8*1)+(7*6)+(6*1)+(5*7)+(4*4)+(3*5)+(2*3)+(1*3)=131
131 % 10 = 1
So 161745-33-1 is a valid CAS Registry Number.

161745-33-1Downstream Products

161745-33-1Relevant articles and documents

Low-Temperature Nickel-Catalyzed C?N Cross-Coupling via Kinetic Resolution Enabled by a Bulky and Flexible Chiral N-Heterocyclic Carbene Ligand

Hong, Xin,Shi, Shi-Liang,Wang, Zi-Chao,Xie, Pei-Pei,Xu, Youjun

supporting information, p. 16077 - 16084 (2021/06/17)

The transition-metal-catalyzed C?N cross-coupling has revolutionized the construction of amines. Despite the innovations of multiple generations of ligands to modulate the reactivity of the metal center, ligands for the low-temperature enantioselective amination of aryl halides remain a coveted target of catalyst engineering. Designs that promote one elementary reaction often create bottlenecks at other steps. We here report an unprecedented low-temperature (as low as ?50 °C), enantioselective Ni-catalyzed C?N cross-coupling of aryl chlorides with sterically hindered secondary amines via a kinetic resolution process (s factor up to >300). A bulky yet flexible chiral N-heterocyclic carbene (NHC) ligand is leveraged to drive both oxidative addition and reductive elimination with low barriers and control the enantioselectivity. Computational studies indicate that the rotations of multiple σ-bonds on the C2-symmetric chiral ligand adapt to the changing needs of catalytic processes. We expect this design would be widely applicable to diverse transition states to achieve other challenging metal-catalyzed asymmetric cross-coupling reactions.

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