161765-91-9Relevant academic research and scientific papers
Bivalent sialyl X saccharides
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, (2008/06/13)
The present invention relates to bivalent sialyl Lewis X saccharide compounds that inhibit cellular binding to a selectin receptor. Pharmaceutical compositions containing a compound of Formula I, and processes for making and using the same are disclosed.
Ligand recognition by E-selectin: Synthesis, inhibitory activity, and conformational analysis of bivalent sialyl Lewis x analogs
DeFrees, Shawn A.,Kosch, Winfried,Way, William,Paulson, James C.,Sabesan, Subramanian,Halcomb, Randall L.,Huang, Dee-Hua,Ichikawa, Yoshitaka,Wong, Chi-Huey
, p. 66 - 79 (2007/10/02)
Several sialyl Lewis x dimers anchored onto a galactose template or attached to 1,4-butanediol or 1,5-pentanediol have been prepared chemoenzymatically and evaluated as inhibitors of E-selectin-mediated cell adhesion. Two monosaccharide units were simulta
