161778-01-4

Basic information

• Product Name: 3,5-Dibromo-α-(2-methoxyphenyl)benzenemethanol
• Synonyms: 3,5-Dibromo-α-(2-methoxyphenyl)benzenemethanol
• CAS NO: 161778-01-4
• Molecular Weight: 372.056
• Mol File: 161778-01-4.mol

Chemical Properties

• CAS DataBase Reference: 3,5-Dibromo-α-(2-methoxyphenyl)benzenemethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-Dibromo-α-(2-methoxyphenyl)benzenemethanol(161778-01-4)
• EPA Substance Registry System: 3,5-Dibromo-α-(2-methoxyphenyl)benzenemethanol(161778-01-4)

Safety Data

• Hazardous Substances Data: 161778-01-4(Hazardous Substances Data)

Upstream product

• 626-39-1 1,3,5-trisbromobenzene 
• 135-02-4 ortho-anisaldehyde 
• 578-57-4 2-bromoanisole 
• 56990-02-4 3,5-dibromobenzaldehyde 
• 86998-01-8 2-bromomethoxybenzene 

Downstream Products

• 214406-53-8 (E)-3-{3-((E)-2-Ethoxycarbonyl-vinyl)-5-[hydroxy-(2-methoxy-phenyl)-methyl]-phenyl}-acrylic acid ethyl ester 
• 161778-26-3 3-[3-(2-Ethoxycarbonyl-ethyl)-5-(2-methoxy-benzyl)-phenyl]-propionic acid ethyl ester 
• 161778-37-6 3-[3-(2-Carbamoyl-ethyl)-5-(2-methoxy-benzyl)-phenyl]-propionic acid ethyl ester 
• 161778-32-1 3-[3-(2-Ethoxycarbonyl-ethyl)-5-(2-methoxy-benzyl)-phenyl]-propionic acid 

Relevant articles and documents

Thromboxane modulating agents. 4. Design and synthesis of 3-(2-[{(4- chlorophenyl)sulfonyl}-amino]ethyl)benzenepropanoic acid derivatives as potent thromboxane receptor antagonists

The design of a series of thromboxane receptor antagonists based on 3- (2-[{(4-chlorophenyl)sulfonyl}amino]ethyl)benzenepropanoic acid (1) is described. Addition of an arylmethyl group at the 5-position of 1 gave exceptionally potent agents in vitro and in vivo, with 13a (UK-147,535) giving complete blockade of the TxA2 receptor for greater than 12 hours in dogs, following an oral dose of 0.1 mg/kg.

BENZENEALKANOIC ACIDS FOR CARDIOVASCULAR DISEASES

Compounds of formula (I) wherein R 1, R 2, R 3 and R 4 are each H or C 1-C 4 alkyl; R 5 is (CH 2) m NHSO. sub.2 R 6 or (CH) m NHCOR 6 ; R 6 is C 1-C 6 alkyl, C 3-C 6 cycloalkyl optionally substituted by aryl, aryl or heteroaryl; R 7 is H, C 1-C 4 alkyl, C