16178-42-0

Basic information

• Product Name: 5-HYDROXYMETHYLQUINOLINE
• Synonyms: 5-HYDROXYMETHYLQUINOLINE;QUINOLIN-5-YLMETHANOL;RARECHEM AK ML 0558;QUINOLINE-5-METHANOL, 97+%;Quninoline-5-methanol;5-quinolinemethanol;Quinoline-5-methanol;quinolin-5-ylmethanol(SALTDATA: FREE)
• CAS NO: 16178-42-0
• Molecular Formula: C₁₀H₉NO
• Molecular Weight: 159.18
• Product Categories: Quinoline Derivertives
• Mol File: 16178-42-0.mol
• Article Data: 7

Chemical Properties

• Melting Point: 136-137 °C
• Boiling Point: 334.833 °C at 760 mmHg
• Flash Point: 156.302 °C
• Appearance: /
• Density: 1.219 g/cm³
• Vapor Pressure: 4.92E-05mmHg at 25°C
• Refractive Index: 1.667
• Storage Temp.: 2-8°C
• PKA: 13.97±0.10(Predicted)
• CAS DataBase Reference: 5-HYDROXYMETHYLQUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-HYDROXYMETHYLQUINOLINE(16178-42-0)
• EPA Substance Registry System: 5-HYDROXYMETHYLQUINOLINE(16178-42-0)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 16178-42-0(Hazardous Substances Data)

Usage

General Description

5-HYDROXYMETHYLQUINOLINE is a chemical compound with the molecular formula C10H9NO2. It is a derivative of quinoline, and its structure includes a hydroxymethyl group attached to the quinoline ring. 5-HYDROXYMETHYLQUINOLINE has various industrial applications, including its use as a chelating agent, corrosion inhibitor, and as a precursor in the synthesis of pharmaceuticals and agrochemicals. 5-HYDROXYMETHYLQUINOLINE has been studied for its potential as an antimalarial agent due to its ability to inhibit the growth of Plasmodium falciparum, the parasite responsible for malaria. 5-HYDROXYMETHYLQUINOLINE also exhibits antioxidant properties, making it a potential candidate for use in nutritional supplements and cosmetic products.

InChI:InChI=1/C10H9NO/c12-7-8-3-1-5-10-9(8)4-2-6-11-10/h1-6,12H,7H2

Upstream product

• 16675-62-0 methyl quinoline-5-carboxylate 
• 7250-53-5 quinoline-5-carboxylic acid 
• 77934-74-8 2-Methyl-benzoic acid quinolin-5-ylmethyl ester 
• 98421-25-1 quinoline-5-carboxylic acid ethyl ester 
• 22934-41-4 quinoline-5-carbaldehyde 

Downstream Products

• 110333-07-8 5-(chloromethyl)quinoline 
• 555155-04-9 2-(quinolin-5-yl)acetonitrile 
• 98421-29-5 5-(2-benzamidoethyl)quinoline 
• 98421-32-0 5-(2-benzamidoethyl)carbostyril 
• 98421-31-9 5-(2-benzamidoethyl)quinoline N-oxide 
• 98421-28-4 5-(2-aminoethyl)quinoline 
• 1260796-73-3 5-bromomethyl-quinoline 

Relevant articles and documents

Pyrimidinone Derivatives as Antimalarial Agents

The invention relates to novel pyrimidinone-based heterocyclic compounds which are parasite growth inhibitors, having the general formula (I) in which Y is a morpholine chosen from three bridged morpholines, L is a bond or a linker, n=0 or 1 and R2 is a methyl group when n=0 and a hydrogen atom when n=1. Process for the preparation thereof and therapeutic use thereof.

PYRIMIDINONE DERIVATIVES AS ANTIMALARIAL AGENTS

The invention relates to novel pyrimidinone-based heterocyclic compounds which are parasite growth inhibitors, having the general formula (I) in which Y is a morpholine chosen from three bridged morpholines, L is a bond or a linker, n = 0 or 1 and R2 is a methyl group when n = 0 and a hydrogen atom when n = 1. Process for the preparation thereof and therapeutic use thereof.

Pyrimidine derivatives useful as inhibitors of PKC-theta

Disclosed are novel compounds of formula (I): wherein X, Y, R1, R2 and R3 are as defined herein, which are useful as inhibitors of PKC-theta and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC-theta, including immunological disorders and type II diabetes. This invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.