161795-97-7Relevant academic research and scientific papers
BACE-2 INHIBITORY COMPOUNDS AND RELATED METHODS OF USE
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Paragraph 0145; 0146, (2017/05/02)
Provided herein are novel compounds of Formulae I-III, and methods of using the same to selectively inhibit BACE2.
Highly ortho-Selective Chlorination of Anilines Using a Secondary Ammonium Salt Organocatalyst
Xiong, Xiaodong,Yeung, Ying-Yeung
supporting information, p. 16101 - 16105 (2016/12/26)
An organocatalytic, highly facile, efficient, and regioselective ortho-chlorination of anilines is described. A secondary ammonium chloride salt has been employed as the catalyst and the reaction can be conducted at room temperature without protection from air and moisture. In addition, the reaction is readily scalable and the catalyst can be recycled and reused. This catalytic protocol has been applied to the efficient synthesis of a highly potent c-Met kinase inhibitor. Mechanistic studies revealed that unique structural features of the secondary ammonium chloride salt are important for both the catalysis and regioselectivity of the electrophilic ortho-chlorination.
Synthesis of well-defined hyperbranched polyamides by condensation polymerization of AB2 monomer through changed substituent effects
Ohta, Yoshihiro,Fujii, Shuichi,Yokoyama, Akihiro,Furuyama, Taniyuki,Uchiyama, Masanobu,Yokozawa, Tsutomu
supporting information; experimental part, p. 5942 - 5945 (2009/12/08)
Branching out: Condensation polymerization of AB2 monomer proceeds selectively from a core molecule owing to the change of substituent effects between the monomer and the polymer (see scheme). Hyperbranched polyamides are obtained with very low
Construction of well-defined multifunctional dendrimers using a trifunctional core
Ornelas, Catia,Weck, Marcus
supporting information; experimental part, p. 5710 - 5712 (2010/01/31)
A simple synthetic strategy was developed for the synthesis of well-defined multifunctional poly(amide)-based dendrimers using a trifunctional core.
