1618-37-7

Basic information

• Product Name: 4H-Pyrrolo[2,3-d]pyrimidin-4-one, 1,7-dihydro-5-methyl- (9CI)
• Synonyms: 4H-Pyrrolo[2,3-d]pyrimidin-4-one, 1,7-dihydro-5-methyl- (9CI);5-Methyl-3H-pyrrolo[2,3-d]pyriMidin-4(7H)-one;5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ol;5-methyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one;4H-Pyrrolo[2,3-d]pyrimidin-4-one, 3,7-dihydro-5-methyl-
• CAS NO: 1618-37-7
• Molecular Formula: C7H7N3O
• Molecular Weight: 149.14998
• Product Categories: PYRIMIDINE
• Mol File: 1618-37-7.mol
• Article Data: 2

Chemical Properties

• Melting Point: 290-291 °C(Solv: ethanol (64-17-5))
• Boiling Point: 466.1±33.0 °C(Predicted)
• Appearance: /
• Density: 1.51±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 12.47±0.20(Predicted)
• CAS DataBase Reference: 4H-Pyrrolo[2,3-d]pyrimidin-4-one, 1,7-dihydro-5-methyl- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 4H-Pyrrolo[2,3-d]pyrimidin-4-one, 1,7-dihydro-5-methyl- (9CI)(1618-37-7)
• EPA Substance Registry System: 4H-Pyrrolo[2,3-d]pyrimidin-4-one, 1,7-dihydro-5-methyl- (9CI)(1618-37-7)

Safety Data

• Hazardous Substances Data: 1618-37-7(Hazardous Substances Data)

Usage

General Description

4H-Pyrrolo[2,3-d]pyrimidin-4-one, 1,7-dihydro-5-methyl- (9CI) is a chemical compound with the molecular formula C8H8N2O. It is a derivative of pyrrolopyrimidine and exists in a dihydro form with a methyl group at the 5th position. 4H-Pyrrolo[2,3-d]pyrimidin-4-one, 1,7-dihydro-5-methyl- (9CI) is a heterocyclic organic compound that has potential pharmaceutical and medical applications. It may have properties that make it suitable for use as a drug or research tool in the fields of medicine and biochemistry. Its specific characteristics and potential uses may be of interest to researchers and pharmaceutical companies looking to develop new drugs or study biological processes.

Upstream product

• 1020110-72-8 2-amino-4-methyl-1H-pyrrole-3-carboxamide 
• 109-94-4 formic acid ethyl ester 
• 1020110-76-2 C₇H₉N₃O₂ 

Downstream Products

• 1618-36-6 4-chloro-5-methyl-7H-pyrrolo[2,3-d]pyrimidine 

Relevant articles and documents

4-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)-3,6-DIHYDROPYRIDINE-1-(2H)-CARBOXAMIDE DERIVATIVES AS LIMK AND/OR ROCK KINASES INHIBITORS FOR USE IN THE TREATMENT OF CANCER

The present invention concerns a compound of formula (I), in particular as LIMK and/or ROCK kinases inhibitors. The present invention also concerns these new inhibitors for use for the treatment of a condition selected in the group consisting of: cancers, virion infections, ocular hypertension and glaucoma formation, Neurofibromatosis type 1 and 2, psoriatic lesions, inflammatory diseases and hyperalgesia, central sensitization and chronic pain, reproduction erectile dysfunction, and neuronal diseases. The present description discloses the syntheses and characterisation of exemplary compounds as well as pharmacological data thereof (e.g. pages 32 to 127; examples 1 to 96; families 1 to 8; compounds; biological studies; tables). An exemplary compound is e.g. 4-(5-m ethyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-N-phenyl-3,6-dihydropyridine-1-(2H)-carboxamide (example 1; compound 5).