1618-37-7

Usage

Uses

Used in Pharmaceutical Industry:
4H-Pyrrolo[2,3-d]pyrimidin-4-one, 1,7-dihydro-5-methyl(9CI) is used as a potential drug candidate for various therapeutic applications. Its specific characteristics and properties make it a promising compound for the development of new drugs targeting various diseases and conditions.
Used in Biochemical Research:
4H-Pyrrolo[2,3-d]pyrimidin-4-one, 1,7-dihydro-5-methyl(9CI) is used as a research tool in the field of biochemistry. Its unique structure and properties may be of interest to researchers studying biological processes and mechanisms, as well as those looking to develop new methods and techniques for drug discovery and development.

Upstream product

• 1020110-76-2 C₇H₉N₃O₂ 
• 1020110-72-8 2-amino-4-methyl-1H-pyrrole-3-carboxamide 
• 109-94-4 formic acid ethyl ester 

Downstream Products

• 1618-36-6 4-chloro-5-methyl-7H-pyrrolo[2,3-d]pyrimidine 

Relevant academic research and scientific papers

4-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)-3,6-DIHYDROPYRIDINE-1-(2H)-CARBOXAMIDE DERIVATIVES AS LIMK AND/OR ROCK KINASES INHIBITORS FOR USE IN THE TREATMENT OF CANCER

The present invention concerns a compound of formula (I), in particular as LIMK and/or ROCK kinases inhibitors. The present invention also concerns these new inhibitors for use for the treatment of a condition selected in the group consisting of: cancers, virion infections, ocular hypertension and glaucoma formation, Neurofibromatosis type 1 and 2, psoriatic lesions, inflammatory diseases and hyperalgesia, central sensitization and chronic pain, reproduction erectile dysfunction, and neuronal diseases. The present description discloses the syntheses and characterisation of exemplary compounds as well as pharmacological data thereof (e.g. pages 32 to 127; examples 1 to 96; families 1 to 8; compounds; biological studies; tables). An exemplary compound is e.g. 4-(5-m ethyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-N-phenyl-3,6-dihydropyridine-1-(2H)-carboxamide (example 1; compound 5).

PROCESS FOR PREPARING 5-ALKYL-7H-PYRROLO[2,3-d] PYRIMINDINE-2-OLS

Methods of preparing 5-alkyl-7H-pyrrolo[2,3-d]pyrimidin-4-ols are described, as are novel compounds useful in their preparation. A specific method encompassed by the invention is represented in the following scheme: