1618-47-9Relevant articles and documents
Synthesis of Triptycene-Based Molecular Rotors for Langmuir-Blodgett Monolayers
Kaleta, Ji?í,Kaletová, Eva,Císa?ová, Ivana,Teat, Simon J.,Michl, Josef
, p. 10134 - 10150 (2015)
We describe syntheses of six triptycene-containing molecular rotors with several single-crystal X-ray diffraction analyses. These rod-shaped molecules carrying an axial rotator are designed to interleave on an aqueous surface into Langmuir-Blodgett (LB) monolayers containing a two-dimensional trigonal array of dipoles rotatable about an axis normal to the surface. Monolayer formation was verified with the simplest of the rotor structures. On an aqueous subphase containing divalent cations (Mg2+, Ca2+, Zn2+, Sr2+, or Cd2+), the LB isotherm yielded an area of 53 ± 3 ?2/molecule (monolayer of type A), compatible with the anticipated triangular packing of axes normal to the surface. On pure water, the area is 30 ± 3 ?2/molecule, and it is proposed that in this monolayer (type B), the molecular axes are tilted by 40-45° to a structure similar to those observed in single crystals of related triptycenes. After transfer to a gold surface, ellipsometry and PM IRRAS yield tilt angles of 29 ± 4° (monolayers of type A) and 38 ± 4° (type B). A full-scale examination of monolayers from all the rotors on a subphase and after transfer is underway and will be reported separately.
CATHEPSIN CYSTEINE PROTEASE INHIBITORS
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Page/Page column 65, (2015/09/22)
This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is i
Compounds
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Page/Page column 34, (2009/08/14)
Compounds of Formula (I), compositions containing them, their use in therapy, including their use as antibacterials, for example in the treatment of tuberculosis, and methods for the preparation of such compounds, are provided.