161832-74-2

Basic information

• Product Name: (R)-(+)-2-AMINO-4-METHYL-1,1-DIPHENYL-1-PENTANOL
• Synonyms: (R)-(+)-2-AMINO-4-METHYL-1,1-DIPHENYL-1-PENTANOL;(R)-(+)-2-AMINO-4-METHYL-1,1-DIPHENYLPENTAN-1-OL;(R)-(+)-2-AMINO-4-METHYL-1,1-DIPHENYL-1-PENTANOL, 98% (99% EE/HPLC)
• CAS NO: 161832-74-2
• Molecular Formula: C₁₈H₂₃NO
• Molecular Weight: 269.38
• Product Categories: Amino Alcohols;Chiral Building Blocks;Organic Building Blocks
• Mol File: 161832-74-2.mol
• Article Data: 2

Chemical Properties

• Melting Point: 144-147 °C(lit.)
• Boiling Point: 436.6 ºC at 760 mmHg
• Flash Point: 48 °C
• Appearance: /
• Density: 1.059 g/cm³
• Vapor Pressure: 2.14E-08mmHg at 25°C
• Refractive Index: 1.569
• PKA: 11.41±0.42(Predicted)
• CAS DataBase Reference: (R)-(+)-2-AMINO-4-METHYL-1,1-DIPHENYL-1-PENTANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(+)-2-AMINO-4-METHYL-1,1-DIPHENYL-1-PENTANOL(161832-74-2)
• EPA Substance Registry System: (R)-(+)-2-AMINO-4-METHYL-1,1-DIPHENYL-1-PENTANOL(161832-74-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 2
• Hazardous Substances Data: 161832-74-2(Hazardous Substances Data)

Usage

General Description

(R)-(+)-2-AMINO-4-METHYL-1,1-DIPHENYL-1-PENTANOL is a chemical compound with a unique molecular structure. It is a chiral compound, meaning it has a non-superimposable mirror image, and exists in two enantiomeric forms, with the (R)-(+)-enantiomer being the more biologically active form. It is a tertiary amine that contains a phenyl group and a methyl group, and is used in the synthesis of pharmaceuticals and other organic compounds. (R)-(+)-2-AMINO-4-METHYL-1,1-DIPHENYL-1-PENTANOL has potential applications in medicinal chemistry and drug development due to its chiral nature and pharmacological activity. Further research and studies are being conducted to explore its potential uses in the field of medicine and drug design.

InChI:InChI=1/C18H23NO/c1-14(2)13-17(19)18(20,15-9-5-3-6-10-15)16-11-7-4-8-12-16/h3-12,14,17,20H,13,19H2,1-2H3/t17-/m1/s1

Upstream product

• 328-38-1 (R)-leucine 
• 108-86-1 bromobenzene 
• 5845-53-4 (R)-leucine methyl ester hydrochloride 
• 7517-19-3 methyl (L)-leucinate hydrochloride 
• 100-58-3 phenylmagnesium bromide 

Downstream Products

• 1333234-98-2 C₂₈H₃₈N₂O₄ 
• 1088110-92-2 (R)-N-((R)-1-hydroxy-4-methyl-1,1-diphenylpentan-2-yl)pyrrolidine-2-carboxamide 
• 155906-85-7 (-)-(1S)-bis-m-xylylenediamine 
• 155906-83-5 (S)-2-{[1-(3-{[(E)-(S)-1-(Hydroxy-diphenyl-methyl)-3-methyl-butylimino]-methyl}-phenyl)-meth-(E)-ylidene]-amino}-4-methyl-1,1-diphenyl-pentan-1-ol 

Relevant articles and documents

Large-scale synthesis of Singh's catalyst in a one-pot procedure starting from proline

A practical one-pot procedure for the preparation of Singh's catalyst from either l-/d-proline or Boc-proline is described. The coupling partner, a chiral amino alcohol, can be prepared and used directly without purification from the corresponding amino acid ester. Moreover, a procedure for tert-butoxycarbonyl (Boc) group removal using concentrated HCl in MeOH-DCM was developed and utilized for the multigram-scale synthesis of Singh's catalyst.