1618682-75-9Relevant academic research and scientific papers
Synthetic and mechanistic aspects of the regioselective base-mediated reaction of perfluoroalkyl- and perfluoroarylsilanes with heterocyclic N-oxides
Stephens, David E.,Chavez, Gabriel,Valdes, Martin,Dovalina, Monica,Arman, Hadi D.,Larionov, Oleg V.
, p. 6190 - 6199 (2014)
The scope and mechanistic implications of the direct transformation of heterocyclic N-oxides to 2-trifluoromethyl-, and related perfluoroalkyl- and perfluoroaryl-substituted N-heterocycles has been studied. The reaction is effected by perfluoroalkyl- and perfluorophenyltrimethylsilane in the presence of strong base. In situ displacement of the para-fluoro substituent in the pentafluorophenyl ring and the methoxy group in 8-methoxyquinolines with additional nucleophiles allows for further site-selective refunctionalization of the N-heterocyclic products. This journal is the Partner Organisations 2014.
