161885-91-2

Upstream product

• 1188931-89-6 (R)-ethyl-5-((1R,3aR,7aR)-7a-methyl-4-oxo-octahydro-1H-inden-1-yl)hexanoate 
• 139356-39-1 (1R,3R)-1,3-bis((tert-butyldimethyl)silanyloxy)-5-[2-(diphenylphosphinoyl)-ethylidene]cyclohexane 
• 883214-91-3 C₂₀H₂₃O₃P 

Downstream Products

• 957214-13-0 (5S)-5-((1R,3R,7E,17β)-1,3-bis[tert-butyl(dimethyl)silyloxy]-9,10-secoestra-5,7-dien-17-yl)hexanal 
• 957214-14-1 (5S)-5-((1R,3R,7E,17b)-1,3-bis[tert-butyl(dimethyl)silyloxy]-9,10-secoestra-5,7-dien-17-yl)hexanoic acid 
• 957214-19-6 C₃₈H₇₀O₃Si₂ 
• 1188931-61-4 (R)-N-(2-aminophenyl)-5-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-dihydroxycyclohexylidene)ethylidene)-7a-methyl-octahydro-1H-inden-1-yl)hexanamide 
• 1188931-88-5 2-((R)-5-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-dihydroxycyclohexylidene)ethylidene)-7a-methyl-octahydro-1H-inden-1-yl)hexylamino)-2-oxoethyl ethyl carbonotrithioate 
• 1188931-90-9 (R)-4-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyl-octahydro-1H-inden-1-yl)pentan-1-amine 
• 1188931-91-0 (R)-5-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyl-octahydro-1H-inden-1-yl)hexan-1-amine 
• 1188931-93-2 N-((R)-5-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyl-octahydro-2H-inden-1-yl)hexyl)hydroxylamine 
• 1188932-04-8 methyl (R)-7-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyl-octahydro-2H-inden-1-yl)-2-oxooctanoate 
• 1188931-99-8 N-((R)-5-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyl-octahydro-1H-inden-1-yl)hexyl)-2-bromoacetamide 
• 1188932-06-0 C₄₀H₇₆N₂O₃Si₂ 
• 1188931-96-5 S-2-((R)-4-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyl-octahydro-7H-inden-1-yl)pentylamino)-2-oxoethyl ethanethioate 
• 1188931-94-3 (R)-N-(2-aminophenyl)-5-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyloctahydro-1H-inden-1-yl)hexanamide 
• 1188932-00-4 tert-butyl-N-((R)-4-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyl-octahydro-7H-inden-1-yl)pentyl)sulfamoylcarbamate 

Relevant academic research and scientific papers

Vitamin D receptor agonist/histone deacetylase inhibitor molecular hybrids

Incorporation of zinc-binding groups into the side-chain of 1α,25-dihydroxyvitamin D3 (1,25D) fully bifunctional hybrid molecules which act both as vitamin D receptor agonists and histone deacetylase inhibitors. These bifunctional hybrids displ

HYBRID MOLECULES HAVING MIXED VITAMIN D RECEPTOR AGONISM AND HISTONE DEACETYLASE INHIBITORY PROPERTIES

Hybrid molecules comprising a vitamin D receptor agonist moiety and an HDAC inhibitor moiety are described herein. The HDAC inhibitor moiety can be derived from an HDAC inhibitor comprising a functionality selected from the group consisting of an N-hydrox