161888-65-9

Upstream product

• 98-74-8 4-Nitrobenzenesulfonyl chloride 
• 161888-61-5 21-deoxyconcanolide A 
• 147317-25-7 21-O-methylconcanamycin A 
• 161888-60-4 21-deoxyconcanamycin A 
• 80890-47-7 concanamycin A 

Downstream Products

• 403815-33-8 23-O-(p-nitrobenzenesulfonyl)-9-O-[p-(trifluoroethyldiazirinyl)benzoyl]-21-deoxyconcanolide A 

Relevant academic research and scientific papers

Synthesis of a doubly labelled concanamycin derivative for ATPase binding studies

The synthesis of a doubly labelled concanamycin derivative for binding studies with V- and P-type ATPases is described. The starting point was 21-deoxyconcanolide A (6), which was generated from concanamycin A (1) in three steps and which exhibited the full ATPase inhibitor activity, with the advantage of a stability better than that of 1. Through use of a suitable protecting group for 6, the carbene-generating diazirine residue and 125I were introduced regio- and stereo-selectively. The inhibitory efficacy of the resulting 23-iodo(125I)-9-O-[p-(trifluoroethyldiazirinyl)benzoyl]-21,23- dideoxyconcanolide A (11b) turned out to be high enough for labelling studies. Photoaffinity labelling experiments clearly showed that 11b is a suitable derivative with which to determine the binding site of concanamycin-like compounds in different ATPases.