161891-26-5

Upstream product

• 68-12-2 N,N-dimethyl-formamide 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 37572-24-0 3-amino-5-(4-methoxyphenyl)thiophene-2-carboxylic acid ethyl ester 

Downstream Products

• 130445-93-1 3-cyano-2-methyl-6-(4-methoxyphenyl)pyridine 
• 4385-63-1 2-(4-methoxyphenyl)-6-methyl-pyridine 
• 1620397-64-9 (E)-3-(4-methoxyphenyl)-3-(methylthio)acrylaldehyde 
• 869709-83-1 4-Chloro-6-(4-methoxyphenyl)thieno[3,2-d] pyrimidine 
• 225385-22-8 6-(4-Methoxyphenyl)thieno[3,2-d] pyrimidin-4(3H)-one 
• 1610410-52-0 Ethyl 3-formamido-5-(4-methoxyphenyl)thiophene-2-carboxylate 
• 37572-24-0 3-amino-5-(4-methoxyphenyl)thiophene-2-carboxylic acid ethyl ester 
• 887247-33-8 3-Chloro-3-(4-methoxyphenyl)acrylonitrile 
• 28592-29-2 2-carbethoxy-5-(4-methoxyphenyl)pyrrole 

Relevant academic research and scientific papers

Synthesis of novel β-aryl-β-(methylthio)acroleins via Vilsmeier-Haack protocol as potential 1,3-dielectrophilic three-carbon building blocks

A new general route for the synthesis of novel β-aryl-β- (methylthio)acroleins, a class of stable potential 1,3-dielectrophilic synthons, has been reported. The overall protocol involves treatment of either β-chloroacroleins or their precursor iminium salts (generated in situ from the corresponding active methylene ketones under Vilsmeier-Haack reaction conditions) with S,S-dimethyldithiocarbonates (DDC)/aqueous KOH in either a one-pot or two-step process. The dimethyldithiocarbonate (DDC)/30% aqueous KOH has been shown to be an excellent source of methylthiolate anion.

Thioether derivatives as protein kinase inhibitors

The present invention relates to thioether derivatives as protein kinase inhibitors, which are useful for the treatment, relieve and/or prevention of diseases associated with abnormal and hyperproliferation of cells in a mammal, especially humans, and which are particularly useful for the treatment of all forms of cancer.

The application of unsymmetrical vinylogous iminium salts and related synthons to the preparation of monosubstituted triazolo[1,5-a]pyrimidines

The reaction of vinylogous iminium salts and related analogs with 3-amino-1,2,4-triazole to yield 7-substituted and 5-substituted triazolo[1,5-a]pyrimidines is described.