1619-40-5

Usage

Type of compound

Thiazole derivative

Attached groups

Phenyl group and aminoanilino group

Nitrogen atom

Site for the attachment of phenyl and aminoanilino groups

Usage

Building block in the synthesis of pharmaceuticals and organic materials

Potential applications

Treatment of various diseases (e.g., cancer, infectious diseases)

Chemical structure

Contributes to its utility as an intermediate in producing compounds with diverse biological activities

InChI:InChI=1/C15H13N3S/c16-12-6-8-13(9-7-12)17-15-18-14(10-19-15)11-4-2-1-3-5-11/h1-10H,16H2,(H,17,18)

Upstream product

• 540-72-7 sodium thiocyanide 
• 70-11-1 α-bromoacetophenone 
• 106-50-3 1,4-phenylenediamine 
• 429621-61-4 2-(N-(p-nitro)phenylamino)-4-phenylthiazole 
• 2010-06-2 2-Amino-4-phenylthiazole 

Relevant academic research and scientific papers

SMALL MOLECULE ACTIVATORS OF NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT) AND USES THEREOF

Provided herein are small molecule activators of Nicotinamide Phosphoribosyltransferase (NAMPT), compositions comprising the compounds, and methods of using the compounds and compositions.

Synthesis and Biological Evaluation of N-aryl-4-aryl-1,3-Thiazole-2-Amine Derivatives as Direct 5-Lipoxygenase Inhibitors

Biological evaluation of N-aryl-4-aryl-1,3-thiazole-2-amine derivatives was examined for anti-inflammatory activity in in vitro and in vivo assays. The thiazole compounds showed direct inhibition of 5-lipoxygenase (LOX) that is a key enzyme of leukotrienes synthesis and involved in the inflammation-related diseases, including asthma and rheumatoid arthritis. To optimize biological activity, we synthesized 1,3-thiazole-2-amine derivatives and investigated for structure and activity relationship. Especially, N-(3,5-dimethylphenyl)-4-(4-chlorophenyl)-1,3-thiazole-2-amine was shown to have a potent anti-inflammatory activity as a 5-LOX inhibitor.