1619-91-6

Usage

Uses

Used in Pharmaceutical and Agrochemical Production:
1,1,1,3,3,3-Hexafluoroprop-2-ylamine hydrochloride is used as a building block for the synthesis of pharmaceuticals and agrochemicals due to its high reactivity and stability. It plays a crucial role in the development of various drugs and agricultural chemicals, contributing to the advancement of these industries.
Used in Insecticide and Herbicide Manufacturing:
1,1,1,3,3,3-Hexafluoroprop-2-ylaMine hydrochloride is also used as a key intermediate in the manufacture of insecticides and herbicides. Its properties make it an ideal component for creating effective and stable products that can protect crops and control pests.
Used in Refrigerant and Fire Extinguishing Agent Production:
1,1,1,3,3,3-Hexafluoroprop-2-ylamine hydrochloride is utilized in the production of refrigerants and fire extinguishing agents. Its high thermal stability and low toxicity make it a safe and reliable choice for these applications, ensuring the efficient functioning of refrigeration systems and effective fire suppression.

Upstream product

• 2730-56-5 2-Nitro-heptafluorpropan 
• 92629-24-8 Ethyl N-Hexafluoroisopropoxyoxaminate 
• 1645-75-6 bis(trifluoromethyl)ketimine 

Relevant academic research and scientific papers

Superiority of Very Weakly Basic Amines as Catalysts for Alpha-Proton Abstraction via Iminium Ion Formation

Catalysis of the conversions of beta-ketol 6 and beta-acetoxy ketone 7 to enone 3 via amine-carbonyl condensation has been studied by using eight nontertiary amines having a pKa range from 10.61 to 1.22, including the very weakly basic 3,3,4,4-tetrafluoropyrrolidine (pKa = 4.05) and 1,1,1,3,3,3-hexafluoroisopropylamine (pKa = 1.22).Kinetic terms reflecting rate-determining alpha-proton abstraction via iminium ion formation were identified.Primary kinetic isotope effects were observed when appropriately deuterated 6 and 7 were used.Intermediate eniminium and enimmonium ions 17 were detected.Unlike general-base catalysis, catalysis via iminium ion formation becomes more effective as the base strength of the catalyst decreases.With 1 M hexafluoroisopropylamine as catalyst, formation of 3 from 7 occurs > 104 times via the iminium ion pathway for every time it occurs via direct general-base-catalyzed alpha-proton abstraction.

INVESTIGATION OF METHODS FOR THE SYNTHESIS OF AZIRIDINES AND AZIRINES ON THE BASIS OF ETHYL-β,β-BIS(TRIFLUOROMETHYL) ACRYLATE

Various methods for the preparation of aziridines and azirines on the basis of ethyl β,β-bis(trifluoromethyl)acrylate were studied.Alkaline treatment of the products of addition of nucleophilic reagents to ethyl β,β-bis(trifluoromethyl)acrylate leads to t