161925-59-3

Upstream product

• 134815-49-9 (E)-(2S,6R,8S)-8-<(tert-Butyldimethylsilyl)oxy>-2,4,6-trimethyl-4-nonenoyl-(S)-alanyl-N-methyl-2-bromo-(R)-tryptophanyl-O-methyl-(R)-β-tyrosine Methyl Ester 
• 161925-58-2 methyl (3R,6R,9S,12S,14E,16R,18S)-6-<(2-bromo-1H-indol-3-yl)methyl>-18-benzoyloxy-3-<4-(tert-butyldimethylsilyloxy)phenyl>-7,9,12,14,16-pentamethyl-5,8,11-trioxo-4,7,10-triazanonadeca-14-enoate 
• 119717-37-2 jasplakinolide 
• 3943-97-3 methyl 4-hydroxycinnamate 
• 4397-53-9 p-benzyloxybenzaldehyde 
• 696-62-8 para-iodoanisole 
• 4299-70-1 D-Tryptophan methyl ester 
• 112896-88-5 methyl (R)-3-(2-bromo-1H-indol-3-yl)-2-(N-tert-butoxycarbonyl-N-methylamino)-propanoate 
• 122747-97-1 methyl (R)-3-(1H-indol-3-yl)-2-(N-tert-butoxycarbonyl-N-methylamino)propanoate 
• 134781-90-1 (R)-2-tert-Butyl-6-(4-methoxy-phenyl)-tetrahydro-pyrimidin-4-one 
• 134781-91-2 (R)-3-[(R)-2-[((S)-2-Amino-propionyl)-methyl-amino]-3-(2-bromo-1H-indol-3-yl)-propionylamino]-3-(4-methoxy-phenyl)-propionic acid methyl ester 
• 134781-82-1 (R)-β-Tyrosine Methyl Ether Methyl Ester hydrochloride 
• 134781-88-7 D-N-formyl tryptophan methyl ester 
• 134781-84-3 (E)-(6R,8S)-8-<(tert-Butyldimethylsilyl)oxy>-4,6-dimethyl-4-nonenoic Acid 

Downstream Products

• 119717-37-2 jasplakinolide 

Relevant academic research and scientific papers

Seragamides A-F, new actin-targeting depsipeptides from the sponge Suberites japonicus Thiele

Six new depsipeptides, seragamides A-F (1-6), and a known geodiamolide I (7) have been isolated as cytotoxic metabolites from the Okinawan sponge Suberites japonicus. Their structures were elucidated by means of spectroscopic analysis and chemical transfo

A synthesis of Jaspamide based on 1,2-metallate rearrangements of α-heteroalkenylmetal derivatives

Jaspamide (Jasplakinolide), a marine cyclodepsipeptide, was synthesised from tripeptide fragment 4 and (2S,4E,6R,8S)-8-benzoyloxy-2,4,6-trimethylnon-4-enoic acid (3). The tripeptide fragment was prepared from β-tyrosine derivative 6, Boc-2-bromoabrine (8)

Studies on cyclodepsipeptides - Part II : The total synthesis of jaspamide and geodiamolide-D

The total synthesis of cyclodepsipeptides jaspamide and geodiamolide D have been presented.