161957-56-8

Basic information

• Product Name: 3-Bromo-2-fluorobenzoic acid
• Synonyms: 3-Bromo-2-fluorobenzoic acid 97%;Benzoic acid, 3-bromo-2-fluoro-;BUTTPARK 14\01-30;3-BROMO-2-FLUOROBENZOIC ACID;3-Bromo-2-fluorobenzoic;3-Bromo-2-fluorobenzoic acid 97%+
• CAS NO: 161957-56-8
• Molecular Formula: C₇H₄BrFO₂
• Molecular Weight: 219.01
• Product Categories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Benzoic acid;API intermediates;Acids and Derivatives;Halides
• Mol File: 161957-56-8.mol
• Article Data: 16

Chemical Properties

• Melting Point: 168 °C
• Boiling Point: 298.2 °C at 760 mmHg
• Flash Point: 134.1 °C
• Appearance: white to off-white solid
• Density: 1.789 g/cm₃
• Vapor Pressure: 9.41mmHg at 25°C
• Refractive Index: 1.438
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 2.88±0.10(Predicted)
• CAS DataBase Reference: 3-Bromo-2-fluorobenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Bromo-2-fluorobenzoic acid(161957-56-8)
• EPA Substance Registry System: 3-Bromo-2-fluorobenzoic acid(161957-56-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26
• HazardClass: IRRITANT
• Hazardous Substances Data: 161957-56-8(Hazardous Substances Data)

Usage

Chemical Properties

Off-white powder

Uses

3-Bromo-2-fluorobenzoic acid is used as a reagent to synthesize Dabrafenib, an inhibitor of BRAF kinase that is used to treat BRAF V600-mutation positive carcinoma. BRAF is a gene that mediates cell growth and is activated by mutations caused by cancer. 3-Bromo-2-fluorobenzoic acid is also used as a reagent to prepare Alkynlphenoxyacetic acid receptor agonists, compounds that can be potentially used for the treatment of allergic inflammatory diseases (such as allergic rhinitis).

InChI:InChI=1/C4H2Br2F4/c1-2(5)3(7,8)4(6,9)10/h1H2

Upstream product

• 1072-85-1 o-fluorobromobenzene 
• 109-72-8 n-butyllithium 
• 206551-41-9 2-fluoro-3-bromobenzoic acid methyl ester 
• 124-38-9 carbon dioxide 

Downstream Products

• 261723-32-4 1-bromo-2-fluoro-3-(hydroxymethyl)benzene 
• 374554-41-3 3-bromo-2-fluorobenzoyl chloride 
• 374554-93-5 3-bromo-N-[3-(1,2-dimethyl-1H-imidazol-5-yl)phenyl]-2-fluorobenzamide 
• 206551-41-9 2-fluoro-3-bromobenzoic acid methyl ester 
• 1190223-47-2 3-(5-formylfuran-2-yl)-2-fluorobenzoic acid 
• 1286836-59-6 2-fluoro-3-(5-((4-oxo-2-thioxo-3-(3-(trifluoromethyl)phenyl)thiazolidin-5-ylidene)methyl)-furan-2-yl)benzoic acid 
• 1307255-11-3 1-bromo-2-fluoro-3-(methoxymethyl)benzene 
• 1307255-12-4 C₈H₉FO₂ 
• 1307255-13-5 tert-butyl (3-endo)-3-[2-fluoro-3-(methoxymethyl)phenoxy]-8-azabicyclo[3.2.1]octane-8-carboxylate 
• 1260012-83-6 6-bromo-7-fluoro-2,3-dihydroinden-1-one 
• 1593702-49-8 1-(3-bromo-2-fluorophenyl)-3-chloropropan-1-one 
• 88430-50-6 beraprost 314d 
• 149947-15-9 3-bromo-2-fluorobenzaldehyde 
• 1307272-00-9 N-{3-[5-(2-chloro-4-pyrimidinyl)-2-(4-methyltetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]-2-fluorophenyl}-1-propanesulfonamide 

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