161970-71-4Relevant articles and documents
Water-based conditions for the microscale parallel synthesis of bicyclic lactams
Malaquin, Sandra,Jida, Mouhamad,Courtin, Justin,Laconde, Guillaume,Willand, Nicolas,Deprez, Benoit,Deprez-Poulain, Rebecca
supporting information, p. 562 - 567 (2013/02/23)
We report efficient miniaturized conditions to prepare arrays of bicyclic lactams for screening. The nature of the solvent is usually an important factor of reactivity. At a small synthesis scale, when automated pipetting devices are required, physical pr
Acid-promoted aza-cyclization versus -cyclization of N -acyliminium species into fused pyrrolo[1,2-a]imidazolones and pyrrolo[2,1- a ]isoquinolinones
Fleury, Jean-Fran?ois,Netchita?lo, Pierre,Da?ch, Adam
scheme or table, p. 1821 - 1826 (2011/09/19)
A new approach for the synthesis of fused imidazolones and isoquinolinones is presented. The key step of this sequence was the interception of an N-acyliminium species with nitrogen or -aromatic nucleophiles under kinetic vs. thermodynamic control. In add
A Simple Asymmetric Synthesis of 2-Substituted Pyrrolidines and 5-Substituted Pyrrolidinones
Burgess, Laurence E.,Meyers, A. I.
, p. 1656 - 1662 (2007/10/02)
An efficient procedure for the preparation of the title compounds in high enantiomeric purity has been realized starting from 3-acylpropionic acids.Stereoselective reduction of chiral bicyclic lactams 2a-h, prepared from the corresponding γ-keto acid and