161970-71-4Relevant academic research and scientific papers
Water-based conditions for the microscale parallel synthesis of bicyclic lactams
Malaquin, Sandra,Jida, Mouhamad,Courtin, Justin,Laconde, Guillaume,Willand, Nicolas,Deprez, Benoit,Deprez-Poulain, Rebecca
supporting information, p. 562 - 567 (2013/02/23)
We report efficient miniaturized conditions to prepare arrays of bicyclic lactams for screening. The nature of the solvent is usually an important factor of reactivity. At a small synthesis scale, when automated pipetting devices are required, physical pr
Highly stereoselective double (R)-phenylglycinol-induced cyclocondensation reactions of symmetric aryl bis(oxoacids)
Amat, Mercedes,Arroniz, Carlos,Molins, Elies,Escolano, Carmen,Bosch, Joan
scheme or table, p. 2175 - 2184 (2011/05/08)
The double cyclocondensation of symmetric pyridyl bis(oxoacids) 2b and 3b with (R)-phenylglycinol stereoselectively gave access to bis-phenylglycinol- derived oxazolopyrrolidine 9 and oxazolopiperidone 10, respectively. Application of the stereocontrolled
Acid-promoted aza-cyclization versus -cyclization of N -acyliminium species into fused pyrrolo[1,2-a]imidazolones and pyrrolo[2,1- a ]isoquinolinones
Fleury, Jean-Fran?ois,Netchita?lo, Pierre,Da?ch, Adam
scheme or table, p. 1821 - 1826 (2011/09/19)
A new approach for the synthesis of fused imidazolones and isoquinolinones is presented. The key step of this sequence was the interception of an N-acyliminium species with nitrogen or -aromatic nucleophiles under kinetic vs. thermodynamic control. In add
Solvent-free microwave-assisted Meyers' lactamization
Jida, Mouhamad,Deprez-Poulain, Rebecca,Malaquin, Sandra,Roussel, Pascal,Agbossou-Niedercorn, Francine,Deprez, Benoit,Laconde, Guillaume
experimental part, p. 961 - 964 (2010/08/04)
Microwave solvent-free conditions developed for Meyers' lactamization, a typical bielectrophile-binucleophile reaction that produces quaternary centers in a stereoselective manner, give access to Meyers' chiral lactams in good yield and high diastereosele
A Simple Asymmetric Synthesis of 2-Substituted Pyrrolidines and 5-Substituted Pyrrolidinones
Burgess, Laurence E.,Meyers, A. I.
, p. 1656 - 1662 (2007/10/02)
An efficient procedure for the preparation of the title compounds in high enantiomeric purity has been realized starting from 3-acylpropionic acids.Stereoselective reduction of chiral bicyclic lactams 2a-h, prepared from the corresponding γ-keto acid and
A Simple Asymmetric Synthesis of 2-Substituted Pyrrolidines from 3-Acylpropionic Acids
Meyers, A. I.,Burgess, Laurence E.
, p. 2294 - 2296 (2007/10/02)
The title compounds have been prepared from 3-acylpropionic acids 2 and (-)-R-phenylglycinol in a three-step sequence in >98percent enantiomeric excess.The R group in 2 ultimately becomes the 2-substituent in the chiral pyrrolidine.
