161978-95-6

Upstream product

• 160531-35-1 Trifluoro-acetic acid (3R,9S,11S,13R,14S,16S)-3-[4-(tert-butyl-dimethyl-silanyloxy)-3-iodo-benzyl]-16-isopropyl-4,9,11,13-tetramethyl-2,5,8-trioxo-1-oxa-4,7-diaza-cyclohexadec-14-yl ester 
• 162061-65-6 4-Nitro-benzoic acid (1S,2R,4S,6S)-1-((S)-2-benzyloxy-3-methyl-butyl)-6-methoxycarbonyl-2,4-dimethyl-heptyl ester 
• 160531-19-1 (2S,3R,4S,5R,7S)-7-Benzyloxy-3-(imidazole-1-carbothioyloxy)-5-methoxymethoxy-2,4,8-trimethyl-nonanoic acid methyl ester 
• 160531-30-6 [(2S,4S,6R,7S,9S)-9-Benzyloxy-7-(tert-butyl-dimethyl-silanyloxy)-2,4,6,10-tetramethyl-undecanoylamino]-acetic acid tert-butyl ester 
• 160531-42-0 (S)-3-((2S,3R,4S,6R,7R,9S)-9-Benzyloxy-3-hydroxy-7-methoxymethoxy-2,4,6,10-tetramethyl-undecanoyl)-4-isopropyl-oxazolidin-2-one 
• 160531-40-8 (S)-3-((2S,3R,4R,5R,7S)-7-Benzyloxy-3-hydroxy-5-methoxymethoxy-2,4,8-trimethyl-nonanoyl)-4-isopropyl-oxazolidin-2-one 
• 160531-32-8 (R)-2-((tert-butoxycarbonyl)(methyl)amino)-3-(4-((tert-butyldimethylsilyl)oxy)-3-iodophenyl)propanoic acid 
• 160531-31-7 tert-butyl N-[(2S,4S,6R,7S,9S)-7-{[tert-butyl(dimethyl)silyl]oxy}-9-hydroxy-2,4,6,10-tetramethylundecanoyl]glycinate 
• 160531-43-1 (2S,3R,4S,6R,7R,9S)-9-Benzyloxy-3-hydroxy-7-methoxymethoxy-2,4,6,10-tetramethyl-undecanoic acid methyl ester 
• 162061-66-7 (2S,4S,6R,7S,9S)-9-Benzyloxy-7-(tert-butyl-dimethyl-silanyloxy)-2,4,6,10-tetramethyl-undecanoic acid 
• 160531-16-8 (S)-3-((2S,3R,5S)-5-Benzyloxy-3-hydroxy-2,6-dimethyl-heptanoyl)-4-isopropyl-oxazolidin-2-one 
• 160531-22-6 (2S,4S,6R,7R,9S)-9-Benzyloxy-7-methoxymethoxy-2,4,6,10-tetramethyl-undecanoic acid methyl ester 
• 160531-46-4 (2S,4S,6R,7R,9S)-9-Benzyloxy-7-hydroxy-2,4,6,10-tetramethyl-undecanoic acid methyl ester 
• 160531-18-0 (2S,3R,4R,5R,7S)-7-Benzyloxy-3-hydroxy-5-methoxymethoxy-2,4,8-trimethyl-nonanoic acid methyl ester 

Downstream Products

• 161978-98-9 deoxydoliculide silyl ether 
• 161978-97-8 (3R,9S,11S,13S,16S)-3-[4-(tert-Butyl-dimethyl-silanyloxy)-benzyl]-16-isopropyl-4,9,11,13-tetramethyl-1-oxa-4,7-diaza-cyclohexadecane-2,5,8-trione 
• 161978-96-7 Imidazole-1-carbothioic acid O-{(3R,9S,11S,13R,14S,16S)-3-[4-(tert-butyl-dimethyl-silanyloxy)-benzyl]-16-isopropyl-4,9,11,13-tetramethyl-2,5,8-trioxo-1-oxa-4,7-diaza-cyclohexadec-14-yl} ester 

Relevant academic research and scientific papers

Enantioselective Total Synthesis of Doliculide, a Potent Cytotoxic Cyclodepsipeptide of Marine Origin and Structure-Cytotoxicity Relationships of Synthetic Doliculide Congeners

The total synthesis of doliculide (1), a potent cytotoxic cyclodepsipeptide from the Japanese sea hare Dolabella auricularia, has been achieved.The key step of the synthesis is the construction of the sereogenic centers of a 15-carbon polyketide-derived d