161985-43-9

Upstream product

• 54780-30-2 2-lithio-1,1-diethoxy-2-propene 
• 161985-42-8 (4R,5S)-3-((S)-3-Benzyloxy-2-methoxy-propionyl)-4-methyl-5-phenyl-oxazolidin-2-one 
• 3587-60-8 Benzyloxymethyl chloride 

Downstream Products

• 161985-49-5 (3S,4S,6R,7S)-8-Benzyloxy-6-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-1-((4R,5S,6R)-6-isopropyl-2,2,5-trimethyl-[1,3]dioxan-4-yl)-7-methoxy-3-methyl-5-methylene-octan-2-one 
• 161985-50-8 (3S,4R,5S,6R,7S)-8-Benzyloxy-6-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-1-((4R,5S,6R)-6-isopropyl-2,2,5-trimethyl-[1,3]dioxan-4-yl)-7-methoxy-3,5-dimethyl-octan-2-one 
• 161985-45-1 (3R,4S)-5-Benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-4-methoxy-2-methylene-pentanal 
• 161985-44-0 (3R,4S)-5-Benzyloxy-2-diethoxymethyl-4-methoxy-pent-1-en-3-ol 

Relevant academic research and scientific papers

Stereocontrolled Aldol Additions to α-Methylene-β-Alkoxy Aldehydes: Application to the Synthesis of a C13-C25 Segment of Bafilomycin A1.

A boron-mediated, syn-aldol coupling between ethyl ketone 8 and aldehyde 9, followed by directed hydrogenation at C16 and acetonide hydrolysis, gives the C13-C25 segment 6 of bafilomycin A1.