1619929-39-3Relevant academic research and scientific papers
From 4,5,6,7-tetrahydroindoles to 3- or 5-(4,5,6,7-tetrahydroindol-2-yl) isoxazoles in two steps: A regioselective switch between 3- and 5-isomers
Sobenina, Lyubov N.,Tomilin, Denis N.,Gotsko, Maxim D.,Ushakov, Igor A.,Mikhaleva, Albina I.,Trofimov, Boris A.
, p. 5168 - 5174 (2014/07/08)
(4,5,6,7-Tetrahydroindol-2-yl)alkynes, synthesized by cross-coupling of 4,5,6,7-tetrahydroindoles with aroyl(hetaroyl)bromoalkynes or ethyl bromopropynoate in the presence of K2CO3, regioselectively cyclize with hydroxylamine to eith
From 4,5,6,7-tetrahydroindoles to 3- or 5-(4,5,6,7-tetrahydroindol-2-yl)isoxazoles in two steps: A regioselective switch between 3- and 5-isomers
Sobenina, Lyubov N.,Tomilin, Denis N.,Gotsko, Maxim D.,Ushakov, Igor A.,Mikhaleva, Albina I.,Trofimov, Boris A.
, p. 5168 - 5174 (2014/12/10)
(4,5,6,7-Tetrahydroindol-2-yl)alkynes, synthesized by cross-coupling of 4,5,6,7-tetrahydroindoles with aroyl(hetaroyl)bromoalkynes or ethyl bromopropynoate in the presence of K2CO3, regioselectively cyclize with hydroxylamine to either 3- or 5-(4,5,6,7-tetrahydroindol-2-yl)isoxazoles depending on the acidity of the reaction mixture: in the presence of acetic acid 3-isomers are formed (ca. 100% selectivity), while under neutral conditions the reaction is switched to 5-isomers (94-97% selectivity).
