1619933-40-2Relevant academic research and scientific papers
Microwave-promoted synthesis of bicyclic azocine-β-lactams from Bis(allenes)
Alcaide, Benito,Almendros, Pedro,Aragoncillo, Cristina,Fernández, Israel,Gómez-Campillos, Gonzalo
, p. 7075 - 7083 (2014/08/18)
A metal-free preparation of structurally novel bicyclic azocine-β-lactams has been developed. The first examples accounting for the preparation of eight-membered rings from bis(allenes) in the absence of metals have been achieved by the thermolysis of nonconjugated 2-azetidinone-tethered bis(allenes) on application of microwave irradiation. This selective carbocyclization reaction has been studied experimentally, and additionally, its mechanism has been investigated by a DFT study.
