1619935-40-8

Basic information

• Product Name: 3-acetyl-7-(4-((2-((p-tolylamino)methyl)-1H-benzo[d]imidazol-1-yl)methyl)benzyloxy)-2H-chromen-2-one
• Synonyms: 3-acetyl-7-(4-((2-((p-tolylamino)methyl)-1H-benzo[d]imidazol-1-yl)methyl)benzyloxy)-2H-chromen-2-one
• CAS NO: 1619935-40-8
• Molecular Weight: 543.622
• Mol File: 1619935-40-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-acetyl-7-(4-((2-((p-tolylamino)methyl)-1H-benzo[d]imidazol-1-yl)methyl)benzyloxy)-2H-chromen-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-acetyl-7-(4-((2-((p-tolylamino)methyl)-1H-benzo[d]imidazol-1-yl)methyl)benzyloxy)-2H-chromen-2-one(1619935-40-8)
• EPA Substance Registry System: 3-acetyl-7-(4-((2-((p-tolylamino)methyl)-1H-benzo[d]imidazol-1-yl)methyl)benzyloxy)-2H-chromen-2-one(1619935-40-8)

Safety Data

• Hazardous Substances Data: 1619935-40-8(Hazardous Substances Data)

Upstream product

• 95-01-2 2,4-Dihydroxybenzaldehyde 
• 4857-04-9 2-chloromethyl-1H-benzimidazole 
• 1398531-06-0 3-acetyl-7-(4-(bromomethyl)benzyloxy)-2H-chromen-2-one 
• 6017-57-8 N-(1H-1,3-benzimidazol-2-ylmethyl)-N-(4-methylphenyl)amine 
• 10441-27-7 3-acetyl-7-hydroxy-chromen-2-one 
• 95-54-5 1,2-diamino-benzene 

Relevant articles and documents

Design, synthesis, and biological evaluation of novel benzimidazole derivatives and their interaction with calf thymus DNA and synergistic effects with clinical drugs

A series of new benzimidazole derivatives was synthesized and characterized by IR, 1H NMR, 13C NMR, MS, and HRMS spectra. All the new compounds were screened for their antimicrobial activities in vitro by a twofold serial dilution technique. The bioactive evaluation showed that 3,5-bis(trifluoromethyl)phenyl benzimidazoles were comparably or even more strongly antibacterial and antifungal than the reference drugs Chloromycin, Norfloxacin, and Fluconazole. The combination of 2,4-difluorobenzyl benzimidazole derivative 5l and its hydrochloride 7 respectively with the antibacterials Chloromycin, Norfloxacin, and the antifungal Fluconazole was more sensitive to methicillin-resistant MRSA and Fluconazole-insensitive A. flavus. In addition, the interaction of compound 5l with calf thymus DNA demonstrated that this compound could effectively intercalate into DNA to form a compound 5l-DNA complex that might block DNA replication and thereby exert good antimicrobial activity.