1620057-35-3Relevant academic research and scientific papers
Access to Acyclic Z-Enediynes by Alkyne Trimerization: Cooperative Bimetallic Catalysis Using Air as the Oxidant
Lee, Jin Tu Danence,Zhao, Yu
, p. 13872 - 13876 (2016)
Presented herein is a mild, operationally simple, mix-and-go procedure for the synthesis of acyclic trisubstituted Z-enediynes, from readily available terminal alkynes, in good yields. This method stems from a serendipitous discovery, and makes use of cooperative palladium/copper bimetallic catalysis and air as an oxidant to effect an intriguing alkyne trimerization to yield the valuable Z-enediyne moiety.
A phosphine-mediated stereocontrolled synthesis of Z-enediynes by a vicinal dialkynylation of ethynylphosphonium salts
Reichl, Kyle D.,Radosevich, Alexander T.
supporting information, p. 9302 - 9305 (2014/08/05)
Z-Enediynes are prepared by a vicinal dialkynylation of triaryl(arylethynyl)phosphonium cations. The method, which proceeds under mild transition metal-free conditions, can be conducted on multigram scale as a one-pot, phosphine-mediated synthetic cycle giving enediyne products with excellent control of configuration.
