1620084-74-3

Basic information

• Product Name: (2E,4E,6E,8E)-3,7-dimethyl-9-{6,6-dimethyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolanyl)-1-cyclohexenyl}-2,4,6,8-nonatetraenoicacid ethyl ester
• Synonyms: (2E,4E,6E,8E)-3,7-dimethyl-9-{6,6-dimethyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolanyl)-1-cyclohexenyl}-2,4,6,8-nonatetraenoicacid ethyl ester
• CAS NO: 1620084-74-3
• Molecular Weight: 440.431
• Mol File: 1620084-74-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2E,4E,6E,8E)-3,7-dimethyl-9-{6,6-dimethyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolanyl)-1-cyclohexenyl}-2,4,6,8-nonatetraenoicacid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (2E,4E,6E,8E)-3,7-dimethyl-9-{6,6-dimethyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolanyl)-1-cyclohexenyl}-2,4,6,8-nonatetraenoicacid ethyl ester(1620084-74-3)
• EPA Substance Registry System: (2E,4E,6E,8E)-3,7-dimethyl-9-{6,6-dimethyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolanyl)-1-cyclohexenyl}-2,4,6,8-nonatetraenoicacid ethyl ester(1620084-74-3)

Safety Data

• Hazardous Substances Data: 1620084-74-3(Hazardous Substances Data)

Upstream product

• 2979-10-4 ethyl 2,2-dimethyl-6-oxocyclohexane-1-carboxylate 
• 39760-56-0 triethyl 3-methyl-4-phosphonocrotonate 
• 1620084-73-2 (2E,4E)-3-methyl-5-{6,6-dimethyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolanyl)-1-cyclohexenyl}-2,4-pentadienal 
• 1257045-68-3 ethyl {6,6-dimethyl-2-(trifluoromethanesulfonyloxy)cyclohexene-1-yl}carboxylate 
• 1620084-68-5 2-(hydroxymethyl)-3,3-dimethylcyclohex-1-en-1-yl trifluoromethanesulfonate 
• 1620084-69-6 6,6-dimethyl-2-(trifluoromethanesulfonyloxy)-1-cyclohexenecarboxaldehyde 
• 1620084-70-9 (2E,4E)-3-methyl-5-{6,6-dimethyl-2-(trifluoromehtanesulfonyloxy)}-2,4-pentadienoicacid ethyl ester 
• 1620084-71-0 (2E,4E)-3-methyl-5-{6,6-dimethyl-2-(trifluoromethanesulfonyloxy)-1-cyclohexenyl}-2,4-pentadien-1-ol 
• 1620084-72-1 (2E,4E)-3-methyl-5-{6,6-dimethyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolanyl)-1-cyclohexenyl}-2,4-pentadienol 

Downstream Products

• 4759-48-2 13-cis-retinoic acid 
• 302-79-4 9-cis-retinoic acid 
• 302-79-4 all-trans-retinoic-acid 
• 1620084-75-4 C₁₉⁽¹¹⁾CH₂₈O₂ 
• 1620084-76-5 13-cis-[¹¹C]retinoic acid 
• 1620084-77-6 9-cis-[¹¹C]retinoic acid 

Relevant articles and documents

Synthesis of 11C-labeled retinoic acid, [11C]ATRA, via an alkenylboron precursor by Pd(0)-mediated rapid C-[11C] methylation

Retinoids are a class of chemical compounds which include both natural dietary vitamin A (retinol) metabolites and active synthetic analogs. Both experimental and clinical studies have revealed that retinoids regulate a wide variety of essential biological processes. In this study, we synthesized 11C-labeled all-trans-retinoic acid (ATRA), the most potent biologically active metabolite of retinol and used in the treatment of acute promyelocytic leukemia. The synthesis of 11C-labeled ATRA was accomplished by a combination of rapid Pd(0)-mediated C-[11C] methylation of the corresponding pinacol borate precursor prepared by 8 steps and hydrolysis. [11C]ATRA will prove useful as a PET imaging agent, particularly for elucidating the improved therapeutic activity of ATRA (natural retinoid) for acute promyelocytic leukemia by comparing with the corresponding PET probe [11C]Tamibarotene (artificial retinoid).