1620102-77-3Relevant academic research and scientific papers
Enantioselective annulations for dihydroquinolones by in situ generation of azolium enolates
Lee, Anna,Younai, Ashkaan,Price, Christopher K.,Izquierdo, Javier,Mishra, Rama K.,Scheidt, Karl A.
, p. 10589 - 10592 (2014)
A convergent, catalytic asymmetric formal [4 + 2] annulation for the synthesis of dihydroquinolones has been developed. Carboxylic acids can be employed as precursors to NHC enolates through an in situ activation strategy. Simultaneous generation of a reactive aza-o-quinone methide under the basic conditions employed for NHC generation leads to a dual activation approach.
