1620146-40-8

Basic information

• Product Name: (Z)-5-(5-bromo-2, 4-dimethoxybenzylidene)thiazolidine-2,4-dione
• Synonyms: (Z)-5-(5-bromo-2, 4-dimethoxybenzylidene)thiazolidine-2,4-dione
• CAS NO: 1620146-40-8
• Molecular Weight: 344.186
• Mol File: 1620146-40-8.mol

Chemical Properties

• CAS DataBase Reference: (Z)-5-(5-bromo-2, 4-dimethoxybenzylidene)thiazolidine-2,4-dione(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-5-(5-bromo-2, 4-dimethoxybenzylidene)thiazolidine-2,4-dione(1620146-40-8)
• EPA Substance Registry System: (Z)-5-(5-bromo-2, 4-dimethoxybenzylidene)thiazolidine-2,4-dione(1620146-40-8)

Safety Data

• Hazardous Substances Data: 1620146-40-8(Hazardous Substances Data)

Upstream product

• 2295-31-0 thiazoline-2,4-dione 
• 130333-46-9 5-bromo-2, 4-dimethoxybenzaldehyde 
• 552845-88-2 5-bromo-4-hydroxy-2-methoxy-benzaldehyde 
• 1227484-24-3 5-bromo-2-methoxy-4-(methoxymethoxy)benzaldehyde 
• 1227484-18-5 5-bromo-2-hydroxy-4-(methoxymethoxy)benzaldehyde 
• 116096-90-3 5-bromo-2,4-dihydroxy-benzaldehyde 
• 95-01-2 2,4-Dihydroxybenzaldehyde 

Downstream Products

• 1620146-45-3 (Z)-5-(5-bromo-2, 4-dimethoxybenzylidene)-3-methylthiazolidine-2,4-dione 

Relevant articles and documents

Design, synthesis and docking study of 5-(substituted benzylidene) thiazolidine-2,4-dione derivatives as inhibitors of protein tyrosine phosphatase 1B

A series of novel 5-(substituted benzylidene)thiazolidine-2,4-dione derivatives was designed, and synthesized based on our previous studies. Also their activities were evaluated as competitive inhibitors of protein tyrosine phosphatase 1B (PTP1B). Compounds 6d-6g, 7b, 7c, 7e, 7j, 7k, 7m, 14b and 14e-14f showed potent inhibitory effects against PTP1B, and compound 7e, the most potent among the series, had an IC50 of 4.6 μM. Also a Surflex-Dock docking model of 7e was studied. Compound 7e showed a negative binding energy of -7.35 kcal/mol and a high affinity to PTP1B residues (Gly220, Ala217, Arg221, Asp181, Ser216, Cys215, Phe182, Gln262 and Ile219) in the active sites, indicating that it may stabilize the open form and generate tighter binding to the catalytic sites of PTP1B.