1620147-46-7

Upstream product

• 109-01-3 1-methyl-piperazine 
• 1620147-43-4 N-(5-(chloromethyl)-2-methylphenyl)-4-((4-(4-(trifluoromethoxy)phenyl)thieno[2,3-d]pyrimidin-2-yl)amino)benzamide 
• 139301-27-2 4-trifluoromethoxyphenylboronic acid 
• 1620147-31-0 2-chloro-4-(4-(trifluoromethoxy)phenyl)thieno[2,3-d]pyrimidine 
• 18740-39-1 2,4-dichlorothieno[2,3-d]pyrimidine 

Relevant academic research and scientific papers

Five-membered heteroaromatic ring fused-pyrimidine derivatives: Design, synthesis, and hedgehog signaling pathway inhibition study

A series of novel five-membered heteroaromatic ring fused-pyrimidine derivatives including purines, pyrrolo[2,3-d]pyrimidines, pyrrolo[3,2-d] pyrimidines, thieno[2,3-d]pyrimidines, thieno[3,2-d]pyrimidines and furo[3,2-d]pyrimidines have been identified to be potent inhibitors of hedgehog signaling pathway. The synthesis and SAR of these compounds are described. Among this new series of hedgehog signaling pathway inhibitors, most compounds exhibited significant inhibitory activity compared to vismodegib, indicating that the five-membered heteroaromatic ring fused-pyrimidines stand out as encouraging scaffolds among the currently reported structural skeletons for hedgehog signaling pathway inhibitors, deserving more exploration and further investigation.