1620158-86-2Relevant academic research and scientific papers
Efficient synthesis of 2H & 13C labeled benzaldehydes via regio-selective formylation
Boga, Sobhana B.,Alhassan, Abdul B.,Hesk, David
, p. 4442 - 4444 (2014/08/05)
Benzaldehydes are important building blocks in synthetic organic chemistry that have wide applications for the synthesis of natural products and pharmaceutical drugs. Herein we report a general synthetic methodology for the synthesis of highly functionalized 2H and 13C labeled benzaldehydes in transfer of isotopic purity >99% via regio-selective formylation. Regio-selective deprotonation of substituted benzene 1 with LDA/n-BuLi at -78 °C and treatment with DMF-d7 or EtO- 13CHO led to the synthesis of 2-deutero-1,3-disubstituted benzaldehydes 2/4 in moderate to good yields. The synthetic methodology described represents a simple yet versatile route to functionalized formyl-deuterated, tritiated 13C and 14C labeled benzaldehydes.
