1620161-67-2Relevant academic research and scientific papers
A simple and convenient method for synthesis of new aminonaphthoquinones derived from lawsone by catalytic multicomponent Mannich reaction
Fiorot, Rodolfo G.,Allochio Filho, Jo?o F.,Pereira, Thieres M.C.,Lacerda Jr., Valdemar,Dos Santos, Reginaldo B.,Rom?o, Wanderson,Greco, Sandro J.
, p. 4373 - 4377 (2014)
A clean, efficient and facile one-pot protocol was developed for the synthesis of a series of new aminonaphthoquinones derived from 2-hydroxy-1,4-naphthoquinone (lawsone) by three-component Mannich reaction using catalytic amount of p-TsOH in CH3CN, at room temperature. At the present work, we improved the yield and significantly reduced the reaction time for several Mannich reactions with different amine and aromatic aldehydes using a non-expensive, mild catalyst and suitable solvent.
