162018-15-7

Upstream product

• 21473-04-1 2',2''-Dimethoxy-[1,3';1',1'';3'',1''']quaterphenyl 
• 190438-59-6 3,3'-dibromobiphenyl-2,2'-diol 
• 98-80-6 phenylboronic acid 
• 86-26-0 2-methoxy-1,1'-biphenyl 
• 115377-97-4 2-(methoxymethoxy)-1,1’-biphenyl 
• 149731-62-4 3-bromo-2-methoxybiphenyl 
• 1806-29-7 2,2'-dihydroxybiphenyl 

Downstream Products

• 1078123-23-5 C₂₄H₁₇O₄P 
• 204762-24-3 6-Chloro-4,8-diphenyl-5,7-dioxa-6-phospha-dibenzo[a,c]cycloheptene 

Relevant academic research and scientific papers

Titanium 3,3′-modified-biphenolate complexes atropisomerically controlled by TADDOLs: Novel chiral Lewis acid catalysts for asymmetric methylation with an achiral methyl-titanium reagent

Chiral Ti complexes, which are constituted of 3,3′-modified-biphenolate (BIPOLate) ligands atropisomerically controlled by (R)-TADDOLs, are shown to be novel chiral Lewis acid catalysts for the methylation reaction of aldehydes with an achiral methyl-tita

Azine Activation via Silylium Catalysis

Practical, efficient, and general methods for the diversification of N-heterocycles have been a recurrent goal in chemical synthesis due to the ubiquitous influence of these motifs within bioactive frameworks. Here, we describe a direct, catalytic, and selective functionalization of azines via silylium activation. Our catalyst design enables mild conditions and a remarkable functional group tolerance in a one-pot setup.

Ammonium Salt-Catalyzed Highly Practical Ortho-Selective Monohalogenation and Phenylselenation of Phenols: Scope and Applications

An ortho-selective ammonium chloride salt-catalyzed direct C-H monohalogenation of phenols and 1,1′-bi-2-naphthol (BINOL) with 1,3-dichloro-5,5-dimethylhydantoin (DCDMH) as the chlorinating agent has been developed. The catalyst loading was low (down to 0.01 mol %) and the reaction conditions were very mild. A wide range of substrates including BINOLs were compatible with this catalytic protocol. Chlorinated BINOLs are useful synthons for the synthesis of a wide range of unsymmetrical 3-aryl BINOLs that are not easily accessible. In addition, the same catalytic system can facilitate the ortho-selective selenylation of phenols.

New carbohydrate bisphosphites as chiral ligands

The synthesis of the 2,3-bisphosphite derivatives of phenyl 4,6-O-benzylidene-β-D-glucopyranoside leads to new chelating ligands. Their rhodium(I) and platinum(II) complexes have been tested as catalysts for the asymmetric hydroformylation of vinyl acetate, allyl acetate and p-methoxystyrene. Good regioselectivity (>90% branched product), but an enantioselectivity of only ≤36% ee were found under mild reaction conditions (25-40°C, 40-70 bar syngas).