1620193-52-3Relevant academic research and scientific papers
Copper-catalyzed direct acyloxylation of C(sp2)-H bonds with Benzoic acids
Zhao, Sheng,Chen, Fa-Jie,Liu, Bin,Shi, Bing-Feng
, p. 1302 - 1309 (2015)
A copper-catalyzed acyloxylation of C(sp2)-H bond with sterically bulky benzoic acids was achieved. This protocol is compatible with a broad range of functional groups and could proceed in gram scale, providing an efficient and practical protoc
Copper-mediated hydroxylation of arenes and heteroarenes directed by a removable bidentate auxiliary
Li, Xin,Liu, Yan-Hua,Gu, Wen-Jia,Li, Bo,Chen, Fa-Jie,Shi, Bing-Feng
supporting information, p. 3904 - 3907 (2014/08/18)
A copper-mediated C-H hydroxylation of arenes and heteroarenes using our newly developed PIP directing group has been developed. This procedure is scalable and compatible with a wide range of functional groups and heteroarenes, providing an operationally simple protocol for the synthesis of o-hydroxybenzamides. The hydroxylation of nicotinamides gave 4-oxo-1,4-dihydropyridine-3-carboxamides selectively. Preliminary mechanistic studies implicate that a basic ligand-enabled, irreversible, rate-determining CMD step is most likely involved in this process.
