1620195-57-4Relevant academic research and scientific papers
Transformations of Isonitriles with Bromoalkanes Using Photoredox Gold Catalysis
Rohe, Samantha,McCallum, Terry,Morris, Avery O.,Barriault, Louis
, p. 10015 - 10024 (2018/07/21)
Isonitriles have excellent electronic compatibility to react with free radicals. Recently, photoredox catalysis has emerged as a powerful tool for the construction of C-C bonds with few protocols for alkylative heterocycle synthesis through isonitrile addition. Herein, we describe the photocatalytic generation of alkyl radicals from unactivated bromoalkanes as part of an efficient cross-coupling strategy for the diversification of isonitriles using a dimeric gold(I) photoredox catalyst, [Au2(dppm)2]Cl2.
A cascade alkylarylation reaction of 2-isocyanobiphenyls with simple alkanes for 6-alkyl phenanthridines via dual C(sp3)-H/C(sp 2)-H functionalizations
Zhu, Zhi-Qiang,Wang, Tian-Tian,Bai, Peng,Huang, Zhi-Zhen
supporting information, p. 5839 - 5842 (2014/08/05)
A cascade alkylarylation reaction of 2-isocyanobiphenyls with simple alkanes for 6-alkyl phenanthridines has been developed through dual C(sp 3)-H/C(sp2)-H functionalizations. The synthetic method has the advantages of high yields, good compatibility of functional groups and mild reaction conditions, although very unreactive alkanes were involved in the reaction. A plausible mechanism through both copper-catalyzed and DTBP mediated pathways has also been proposed. This journal is the Partner Organisations 2014.
