1620199-12-3Relevant academic research and scientific papers
An investigation of in vitro cytotoxicity and apoptotic potential of aromatic diselenides
Rizvi, Masood Ahmad,Guru, Santosh,Naqvi, Tahira,Kumar, Manjeet,Kumbhar, Navanath,Akhoon, Showkat,Banday, Shazia,Singh, Shashank K.,Bhushan, Shashi,Mustafa Peerzada,Shah, Bhahwal Ali
, p. 3440 - 3446 (2014)
A target synthesis of a library of symmetric aromatic diselenides was attempted with the aim of generating anticancer lead compounds. Out of thirteen screened molecules (1-13) against a panel of human cancer cell lines, compound 8 exhibited highest cell growth inhibition in Human leukemia HL-60 cells with IC50 value of 8 μM. Compound 8 had a good pro-apoptotic potential as evidenced from several apoptotic protocols like DNA cell cycle analysis and monitoring of apoptotic bodies formation using phase contrast and nuclear microscopy with Hoechst 33,258. Also, 8 significantly inhibits S phase of the cell cycle and eventually trigger apoptosis in HL-60 cells through mitochondrial dependent pathway substantiated by the loss of mitochondrial potential. A theoretical investigation of DNA binding ability of 8 showed that it selectively bind to minor groove of DNA, where it is stabilized by hydrogen bonding and hydrophobic interactions.
Pullulan drug-carrying system using visible light to induce crosslinking and preparation method thereof
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Paragraph 0060; 0069; 0070; 0071; 0087-0089; 0100-0102, (2018/09/12)
The invention provides a preparation method of a pullulan drug-carrying system using visible light to induce crosslinking, comprising the steps of 1) preparing a dual-selenium compound; 2) preparing apullulan carrier containing the dual-selenium compound;
