1620207-34-2Relevant academic research and scientific papers
Desilylative activation of TMSCN in chemoselective Strecker-Ugi type reaction: Functional fused imidazoles as building blocks as an entry route to annulated purines
Guchhait, Sankar K.,Chaudhary, Vikas
, p. 6694 - 6705 (2014/08/18)
A pathway of desilylative activation of TMSCN as a functional isonitrile equivalent, and DABCO-THF as an appropriate system for activation in a chemoselective Strecker-Ugi type reaction, has rendered ethyl glyoxalate and various heterocyclic-2-amidines as feasible substrates, and afforded the successful synthesis of 3-amino-2-carboxyethyl substituted fused imidazoles as useful building blocks. This class of functional scaffold has provided, via construction of the fused pyrimidinone motif, the synthesis of biologically important C8-N9 annulated purines, adenines and their oxo/thio analogs. This new approach is convenient and flexible for the preparation of versatile purine-condensed heterocycles. This journal is the Partner Organisations 2014.
