1620219-93-3Relevant academic research and scientific papers
Palladium-catalyzed oxidative C-N bond coupling involving a solvent-controlled regioselective bromination process
Ji, Xiaochen,Huang, Huawen,Xiong, Wenfang,Huang, Kunbo,Wu, Wanqing,Jiang, Huanfeng
, p. 7005 - 7011 (2014/08/18)
Stereoselective palladium-catalyzed oxidative C-N bond coupling reactions between aromatic amines and alkenes involving a solvent-controlled regioselective bromination process under 1 atm of oxygen atmosphere are disclosed, providing easy access to two different brominated enamines. The addition of hydrogen peroxide (30% aq) as a co-oxidant in the system is crucial for the dehydrogenative aminohalogenation under molecular oxygen (1 atm), and in such a case, the C-N bond coupling/electrophilic bromination reaction cascade is proposed. Furthermore, the different reaction media leads to a switched regioselectivity of the process.
