1620239-11-3

Upstream product

• 1260807-99-5 ethyl 3-amino-7-bromoquinoline-2-carboxylate 
• 501-53-1 benzyl chloroformate 

Downstream Products

• 1620240-08-5 ethyl 3-{[(benzyloxy)carbonyl]amino}-7-morpholin-4-ylquinoline-2-carboxylate 
• 1620240-66-5 3-{[(benzyloxy)carbonyl]amino}-7-(3-oxopiperazin-1-yl)quinoline-2-carboxylic acid 
• 1620240-35-8 benzyl [2-[({4-[(3S,5R)-3-[(tert-butoxycarbonyl)amino]-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}amino)carbonyl]-7-(3,6-dihydro-2H-pyran-4-yl)quinolin-3-yl]carbamate 
• 1620240-21-2 benzyl {2-[({4-[(3S,5R)-3-amino-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}amino)carbonyl]-7-morpholin-4-ylquinolin-3-yl}carbamate 
• 1620240-14-3 benzyl (2-{[(4-{(3S,5R)-3-[(tert-butoxycarbonyl)amino]-5-methylpiperidin-1-yl}pyridin-3-yl)amino]carbonyl}-7-morpholin-4-ylquinolin-3-yl)carbamate 
• 1620240-06-3 C₃₉H₃₅N₇O₅ 
• 1620240-00-7 C₃₆H₄₀N₆O₆ 
• 1620239-94-2 3-{[(benzyloxy)carbonyl]amino}-7-vinylquinoline-2-carboxylic acid 
• 1620239-89-5 C₄₂H₅₄N₆O₆Si 
• 1620239-85-1 C₄₃H₅₆N₆O₆Si 

Relevant academic research and scientific papers

pyrimidinecarboxamide derivatives and pharmaceutical compositions thereof

The present invention relates to a composition comprising a pyrimidinecarboxamide derivative as an active component, and more specifically, to a pyrimidinecarboxamide derivative, and a composition for preventing, ameliorating, or treating a disease related to the overactivity of PIM serine/threonine kinase enzymes, comprising a pharmaceutically acceptable salt thereof as an active component. According to the present invention, the pyrimidinecarboxamide derivative can be used as a pharmaceutical composition capable of inhibiting or suppressing the activity of PIM serine/threonine kinase enzymes, thereby fundamentally preventing or treating a disease related to the overactivation of PIM serine/threonine kinase enzymes, and can be utilized for the development of a biological agent for the treatment of a disease related to the overactivity of PIM serine/threonine kinase enzymes and various studies on inhibition of the expression or activity of PIM serine/threonine kinase enzymes.

BICYCLIC AROMATIC CARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS

The present disclosure describes bicyclic aromatic carboxamide derivatives, as well as their compositions and methods of use. The compounds inhibit the activity of the Pim kinases, and are useful in the treatment of diseases related to the activity of Pim kinases including, e.g., cancer and other diseases.