1620293-30-2

Upstream product

• 288-13-1 NH-pyrazole 
• 24892-63-5 1-allyloxy-2-iodobenzene 
• 83430-97-1 2-(1H-pyrazol-1-yl)phenol 
• 106-95-6 allyl bromide 

Downstream Products

• 1620291-14-6 1-((5-((2-(1H-pyrazol-1-yl)phenoxy)methyl)-4,5-dihydroisoxazol-3-yl)methyl)-3-(2-methylpyridin-4-yl)urea 
• 1620291-74-8 N-((5-((2-(1H-pyrazol-1-yl)phenoxy)methyl)-4,5-dihydroisoxazol-3-yl)methyl)imidazo[1,2-a]pyridine-6-carboxamide 
• 1620291-75-9 (R)-N-((5-((2-(1H-pyrazol-1-yl)phenoxy)methyl)-4,5-dihydroisoxazol-3-yl)methyl)imidazo[1,2-a]pyridine-6-carboxamide 
• 1620291-76-0 (S)-N-((5-((2-(1H-pyrazol-1-yl)phenoxy)methyl)-4,5-dihydroisoxazol-3-yl)methyl)imidazo[1,2-a]pyridine-6-carboxamide 
• 1620293-34-6 (5-((2-(1H-pyrazol-1-yl)phenoxy)methyl)-4,5-dihydroisoxazol-3-yl)methanamine hydrochloride 
• 1620293-32-4 2-((5-((2-(1H-pyrazol-1-yl)phenoxy)methyl)-4,5-dihydroisoxazol-3-yl)methyl)isoindoline-1,3-dione 

Relevant academic research and scientific papers

Methyl-α-d-glucopyranoside as Green Ligand for Selective Copper-Catalyzed N-Arylation

In the selective N-arylation of amines or azoles with aryl halidesa-, methyl-α-d-glucopyranoside (MG) was found to function as a green ligand of copper powder. In addition, nitrogen heterocyclic amine compounds can also undergo the N-arylation coupling with heterocyclic aryl chlorides. This process allows access to a variety of aromatic amines and aryl azoles under mild reaction conditions, has good tolerance, and proceeds in moderate to high yield.

α-d-Galacturonic Acid as Natural Ligand for Selective Copper-Catalyzed N-Arylation of N-Containing Heterocycles

The first application of α-d-galacturonic acid hydrate (GalA) is reported here, as a potential O-donor ligand. The C-N couplings of N-heterocycles with aryl halides or arylboronic acids could be readily conducted and exhibited good functional group tolerance with characters of selectivity. These N-Arylazoles allow rapid access to several pharmaceutical intermediates and can be easily transformed into a variety of other interesting scaffolds as well.

L -(-) -Quebrachitol as a Ligand for Selective Copper(0)-Catalyzed N-Arylation of Nitrogen-Containing Heterocycles

l-(-)-Quebrachitol (QCT) has been found as a ligand of copper powder for selective N-arylation of nitrogen-containing heterocycles with aryl halides. Furthermore, another potential catalytic system (copper powder/QCT/t-BuOK) was successfully adapted to unactivated aryl chlorides.

4,5-DIHYDROISOXAZOLE DERIVATIVES AS NAMPT INHIBITORS

The present invention provides substituted 4,5-dihydroisoxazole derivatives of formula (I), which may be therapeutically useful, more particularly NAMPT inhibitors and in which R1 R2, Y, X, "Het" and "p" have the meanings given in the specification, and pharmaceutically acceptable salts thereof that are useful in the treatment and prevention of diseases or disorder caused by an elevated level of nicotinamide phosphoribosyltransferase (NAMPT) in a mammal. The present invention also provides preparation of the compounds and pharmaceutical formulations comprising at least one of the substituted 4,5-dihydroisoxazole derivatives of formula (I) or a pharmaceutically acceptable salts or stereoisomers or N-oxide thereof.